Yayınlar & Eserler

SCI, SSCI ve AHCI İndekslerine Giren Dergilerde Yayınlanan Makaleler

Diğer Dergilerde Yayınlanan Makaleler

Hakemli Kongre / Sempozyum Bildiri Kitaplarında Yer Alan Yayınlar

Alzheimer39;s disease (AD) is a neurodegenerative disorder clinically characterized by progressive memory loss and cognitive decline. Pathological hallmarks of the disease are the formation of amyloid plaques and neurofibrillary tangles. Several research has demonstrated that AD-related pathological changes occur long before clinical symptoms are manifested. Thus, it is crucial to establish an accurate diagnosis at an early stage, particularly for individuals aged 60 years and above. Biomarkers serve as vital tools for AD diagnosis, monitoring, early detection, therapeutic intervention, and preventing inaccurate diagnoses. Still, there are no robust tools or biomarkers that can provide precise information for the diagnosis of AD. tRNA-derived fragments (tRFs) are a distinctive type of small non-coding RNAs produced from tRNAs via nucleases Dicer and Angiogenin. tRFs can regulate biological functions such as translation and transcription. Recently, there has been much attention drawn to the previously unexplored connection between tRFs and neurodegenerative disorders. Extracellular vesicles (EVs) are vesicles with lipid membranes and contain numerous different molecules, such as nucleic acids, proteins, and lipids. Within their cargo contents, EVs contribute to development, cell growth, and survival, intercellular communication, and waste disposal, but also to disease pathogenesis. Just like all other cell types, neurons also secrete extracellular vesicles, and neuron-derived extracellular vesicles (NDEVs) may contain distinctive cargoes. In this study, we profiled the tRF content of neuron-derived extracellular vesicles (NDEVs) of AD patients and healthy controls (HCs) with next-generation sequencing. We demonstrated that six tRFs (ProAGG, GluTTC, LysCTT, LeuAAG, SerAGA, ValCAC) were differentially expressed in NDEVs of AD patients compared to HCs. Further, we confirmed those tRFs on a considerably larger population with the RT-qPCR method. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes annotation also indicated that these are enriched in various neuron and brain-related categories; for example, axogenesis (GO:0007409), regulation of nervous system development (GO:0051960), and regulation of neuron projection development (GO:0010975). Taken together, our results indicate that dysregulated tRFs have the potential to serve as a biomarker for AD in future investigations.

The 7th Venusberg Meeting on Neuroinflammation, Luxembourg, Lüksemburg, 11 - 13 Mayıs 2023, ss.1

The effect of M1 and M2 polarized microglia-derived exosomes on neural stem cell differentiation

FENS Forum 2022 | International Neuroscience Conference, Paris, Fransa, 9 - 13 Temmuz 2022, ss.1 Creative Commons License

NEAT1 regulates microglial NLRP3 inflammasome activation

8 International Congress of the Molecular Biology Association of Turkey, İstanbul, Türkiye, 9 - 12 Haziran 2022, ss.1 Sürdürülebilir Kalkınma

LncRNA NEAT1'in mikroglial NLRP3 inflamazom aktivasyonunda düzenleyici rolü

The inflammasomes: The next frontier, Munich, Almanya, 21 - 24 Eylül 2021 Creative Commons License

PAR-2 AND PAR-4 RECEPTORS MEDIATE ANTI-INFLAMMATORY EFFECTS OF ACTIVATED PROTEIN C IN MICROGLIAL CELLS

4th Health Sciences and Innovation Congress, Baku, Azerbaycan, 5 - 06 Temmuz 2021, ss.726-734

Investigation of the effect of melatonin on microRNA expression in the NLRP3 inflammasome model

2nd International Medical Congress of Izmir Democracy University (IMCIDU 2020), İzmir, Türkiye, 17 - 19 Aralık 2020

The protective effect of erythropoietin on apoptotic cell death induced by amyloid beta in PC12 cells.

3rd International Eurasian Conference on Biological and Chemical Sciences, Ankara, Türkiye, 19 - 20 Mart 2020, ss.638-645

ESTIMATION OF GENETIC VARIATION TYPES VIA MACHINE LEARNING

XXI. National and IV. International Biostatistics Congress, Antalya, Türkiye, 26 - 29 Ekim 2019

Ekzozomal MikroRNA ların Santral Sinir Sistemindeki Yeri

16. Tıbbi Biyoloji ve Genetik Kongresi, Bodrum, Türkiye, 27 - 30 Ekim 2019

Microglial phenotypes are determined by variable intracellular hydrogen peroxide concentrations

XIV European Meeting on Glial Cells in Health and Disease, Portekiz, 10 - 13 Temmuz 2019, cilt.67, ss.1

İnfantil Kolik Bir Biyoritim Bozukluğu mudur?

Ulusal Neonatoloji Kongresi (UNEKO 27), Antalya, Türkiye, 3 - 07 Nisan 2019, ss.14

Exosomal microRNAs and microRNA dysregulation in bipolar disorder

21st Annual ISBD Conference on Global Advances in Bipolar Disorder and Depression, Sydney, Avustralya, 20 - 23 Mart 2019, cilt.21, ss.25 identifier

Bilim ve Bilim Akademileri

6th International Congress of theMolecular Biology Associationof Turkey, 5 - 08 Eylül 2018

Nörodejenerasyonda inflamasyonun rolü

ULUSLARARASI KATILIMLI NÖRODEJENERASYON / NÖROREJENERASYON ÇALIŞTAYI, 4 - 05 Mayıs 2018

Altered expressions of exosomal micrornas in bipolar disorder

20th Annual Conference of the International-Society-for-Bipolar-Disorders, Mexico City, Meksika, 7 - 10 Mart 2018, cilt.20, ss.110 identifier

The effects of Dimethyl Fumarate on inflammasome activation in microglial cells

5th International Congrees of Molecular Biology Association of Turkey, 8 - 10 Eylül 2017

mikroRNA ve santral sinir sistemi

14. Ulusal Sinirbilim Kongresi, 26 - 29 Mayıs 2016

Endothelial protein C receptor expression in microglia is regulated by Sp1

12th European Meeting on Glial Cell Function in Health and Disease, Bilbao, İspanya, 15 - 18 Temmuz 2015, cilt.63 identifier

Sulforaphane exerts protective effects in microglial cells by switching polarization phenotypes

12th European Meeting on Glial Cell Function in Health and Disease, Bilbao, İspanya, 15 - 18 Temmuz 2015, cilt.63 identifier

A cell division cycle 7-related protein kinase inhibitor suppresses glioblastoma cell growth in vitro

12th European Meeting on Glial Cell Function in Health and Disease, Bilbao, İspanya, 15 - 18 Temmuz 2015, cilt.63 identifier

Antioxidant effect of Lithium is regulated by microRNA-34a in SH-SY5Y cells

40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Berlin, Almanya, 4 - 09 Temmuz 2015, cilt.282, ss.219 identifier

Serum miR 16 levels show negative correlation with amyloid beta1 42 levels in Alzheimer s disease patients

III. International Congress of the Molecular Biology Association, İzmir, Türkiye, 10 - 12 Eylül 2014, ss.189

Resveratrol decreases hypoxia/reoxygenation induced MMP-2 secretion in human brain microvascular endothelial cells

34th Congress of the Federation-of-European-Biochemical-Societies, Prague, Çek Cumhuriyeti, 4 - 09 Temmuz 2009, cilt.276, ss.198 identifier

The Protective Role of Erytropoietin Against In vitro Ischemia Reperfusion Injury in HUVE Cells In vitro

Mechanisms, Consequences and Detection of Free Radical-Mediated Oxidative Protein Modifications, Antalya, Türkiye, 15 - 20 Nisan 2009, ss.115

In vitro activation of Nrf2-mediated oxidative stress response in human cerebral microvascular endothelial cells by resveratrol

Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference, Athens, Yunanistan, 28 Haziran - 03 Temmuz 2008, cilt.275, ss.308 identifier

Hyperoxia causes cell death in the prefrontal cortex of the developing brain

7th Paediatric Neurology Society (EPNS) Congress, Kuşadası, Türkiye, 26 - 29 Eylül 2007, cilt.11, ss.53

Hyperoxia causes cell death in the hippocampus of the developing brain

7th Paediatric Neurology Society (EPNS) Congress, Kuşadası, Türkiye, 26 - 29 Eylül 2007, cilt.11, ss.52

Effect of in vitro hypoxia and hypoxia/reoxygenation injury on the gelatinases, their inhibitor and activator in endothelial cells

32nd Congress of the Federation-of-European-Biochemical-Societies (FEBS), Vienna, Avusturya, 7 - 12 Temmuz 2007, cilt.274, ss.360 identifier

Potential İnteractions Between Neutrophil Apoptosis and Oxidative Damage in Familial Mediterraen Fever FMF

4th İntenational Congress on Systemic Autoinflammatory Diseases, Bethesda, Maryland, USA, 06 Kasım 2004 - 10 Kasım 2006

Erythropoietin upregulates NF-E2 related factor 2 expression in astroglial cells in vitro

31st Congress of the Federation-of-European-Biochemical-Societies (FEBS), İstanbul, Türkiye, 24 - 29 Haziran 2006, cilt.273, ss.237 identifier

Erythropoietin-conditioned-astrocyte-conditioned medium decreases ethanol neurotoxicity in vitro

31st Congress of the Federation-of-European-Biochemical-Societies (FEBS), İstanbul, Türkiye, 24 - 29 Haziran 2006, cilt.273, ss.236-237 identifier

The effect of erythropoietin on caspase-8 activation induced by amyloid beta in PC12 cells

31st Congress of the Federation-of-European-Biochemical-Societies (FEBS), İstanbul, Türkiye, 24 - 29 Haziran 2006, cilt.273, ss.243-244 identifier

The effect of erythropoietin on antioxidant enzymes and nitric oxide in cytokine activated microglial cultures

European Congress of Clinical Biochemistry and Laboratory Medicine (EUROMEDLAB 2005), Glasgow, Birleşik Krallık, 8 - 12 Mayıs 2005, cilt.355 identifier

The effects of Tc-99m HMPAO labeling on lymphocyte functions

17th Annual Congress of the European-Association-of-Nuclear-Medicine, Helsinki, Finlandiya, 4 - 08 Eylül 2004, cilt.31 identifier

Kitap & Kitap Bölümleri

MicroRNAs in Genetic Etiology of Human Diseases

miRNomics:MicroRNA Biology and Computational Analysis, Jens Allmer,Malik Yousef, Editör, Springer, London/Berlin , New York, ss.255-268, 2022

Role of exosomal microRNAs in cell-to-cell communication

miRNomics:MicroRNA Biology and Computational Analysis, Jens Allmer,Malik Yousef, Editör, Springer, London/Berlin , New York, ss.269-292, 2022

Santral Sinir Sistemi Hastalıklarında Kök Hücre Uygulamaları

Kök Hücre ve Rejeneratif Tıp, Ayşen GÜNEL ÖZCAN, Editör, Türkiye Klinikleri Yayınevi, Ankara, ss.62-66, 2021

Peptide Derivatives of Erythropoietin in the Treatment of Neuroinflammation and Neurodegeneration

Advances in Protein Chemistry and Structural Biology, Rossen Donev, Editör, Academic Press , Cambridge, ss.309-357, 2018

Peptide derivatives of erythropoietin in the treatment of neuroinflammation and neurodegeneration

Therapeutic Proteins and Peptides (Advances in protein chemistry and structural biology, Volume 112), ROSSEN DONEV, Editör, Academic Press , ss.309-357, 2018

Stem Cell-Based Approaches for Treatment of Glioblastoma

Neurological Regeneration, Phuc Van Pham, Editör, Springer, London/Berlin , Lausanne, ss.65-82, 2017

Induced Pluripotent Stem Cell Therapy and Safety Concerns in Age-Related Chronic Neurodegenerative Diseases

Safety, Ethics and Regulations, Pham,Phuc Van,Rosemann,Achim, Editör, Springer, London/Berlin , New York, ss.23-65, 2017

The Role of MicroRNAs in Biological Processes

miRNomics: MicroRNA Biology and Computational Analysis, Malik Yousef,Jens Allmer, Editör, Humana Press, Inc. , New York, ss.15-31, 2014

The role of microRNAs in human diseases

miRNomics: MicroRNA Biology and Computational Analysis, Malik Yousef,Jens Allmer, Editör, Humana Press, Inc. , New York, ss.33-50, 2014

Metrikler

Yayın

172

Atıf (WoS)

3839

H-İndeks (WoS)

32

Atıf (Scopus)

4232

H-İndeks (Scopus)

33

Atıf (Scholar)

44

H-İndeks(Scholar)

2

Atıf (TrDizin)

3

H-Index (TrDizin)

1

Proje

41

Tez Danışmanlığı

24

Açık Erişim

45
BM Sürdürülebilir Kalkınma Amaçları