MIRNOMICS: MICRORNA BIOLOGY AND COMPUTATIONAL ANALYSIS, vol.1107, pp.33-50, 2014 (SCI-Expanded)
Article / Article
MIRNOMICS: MICRORNA BIOLOGY AND COMPUTATIONAL ANALYSIS
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Biomarker, Human disease, Exosome, Mutation, Circulating miRNA, Single nucleotide polymorphism, Copy number variation, COPY-NUMBER VARIATIONS, CELL LUNG-CANCER, CIRCULATING MICRORNAS, OVARIAN-CANCER, BREAST-CANCER, COMPREHENSIVE ANALYSIS, EPIGENETIC REGULATION, GENETIC-VARIATIONS, GERMLINE DELETION, COLORECTAL-CANCER
Dokuz Eylül University Affiliated:
About 20 years have passed since the discovery of the first microRNA (miRNA) and by now microRNAs are implicated in a variety of physiological and pathological processes. Since the discovery of the powerful effect miRNAs have on biological processes, it has been suggested that mutations affecting miRNA function may play a role in the pathogenesis of human diseases. Over the past several years microRNAs have been found to play a major role in various human diseases. In addition, many studies aim to apply miRNAs for diagnostic and therapeutic applications in human diseases. In this chapter, we summarize the role of miRNAs in pathological processes and discuss how miRNAs could be used as disease biomarkers.