The Role of MicroRNAs in Human Diseases

Tufekci K. U., Oner M. G., Meuwissen R. L. J., GENÇ Ş.

MIRNOMICS: MICRORNA BIOLOGY AND COMPUTATIONAL ANALYSIS, cilt.1107, ss.33-50, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1107
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/978-1-62703-748-8_3
  • Dergi Adı: MIRNOMICS: MICRORNA BIOLOGY AND COMPUTATIONAL ANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.33-50
  • Anahtar Kelimeler: Biomarker, Human disease, Exosome, Mutation, Circulating miRNA, Single nucleotide polymorphism, Copy number variation, COPY-NUMBER VARIATIONS, CELL LUNG-CANCER, CIRCULATING MICRORNAS, OVARIAN-CANCER, BREAST-CANCER, COMPREHENSIVE ANALYSIS, EPIGENETIC REGULATION, GENETIC-VARIATIONS, GERMLINE DELETION, COLORECTAL-CANCER
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

About 20 years have passed since the discovery of the first microRNA (miRNA) and by now microRNAs are implicated in a variety of physiological and pathological processes. Since the discovery of the powerful effect miRNAs have on biological processes, it has been suggested that mutations affecting miRNA function may play a role in the pathogenesis of human diseases. Over the past several years microRNAs have been found to play a major role in various human diseases. In addition, many studies aim to apply miRNAs for diagnostic and therapeutic applications in human diseases. In this chapter, we summarize the role of miRNAs in pathological processes and discuss how miRNAs could be used as disease biomarkers.