Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future

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Alural B., GENÇ Ş., Haggarty S. J.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, cilt.73, ss.87-103, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.pnpbp.2016.03.010
  • Dergi Adı: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.87-103
  • Anahtar Kelimeler: Non-coding RNA, MiRNA, Schizophrenia, Bipolar disorder, Neuroplasticity, GENOME-WIDE ASSOCIATION, MAJOR DEPRESSIVE DISORDER, LYMPHOBLASTOID CELL-LINES, 22Q11.2 DELETION SYNDROME, SUPERIOR TEMPORAL CORTEX, PLURIPOTENT STEM-CELLS, RECEPTOR P2RX7 GENE, BIPOLAR DISORDER, PREFRONTAL CORTEX, SCHIZOPHRENIA-PATIENTS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Neuropsychiatric disorders are common health problems affecting approximately 1% of the population. Twin, adoption, and family studies have displayed a strong genetic component for many of these disorders; however, the underlying pathophysiological mechanisms and neural substrates remain largely unknown. Given the critical need for new diagnostic markers and disease-modifying treatments, expanding the focus of genomic studies of neuropsychiatric disorders to include the role of non-coding RNAs (ncRNAs) is of growing interest. Of known types of ncRNAs, microRNAs (miRNAs) are 20-25-nucleotide, single-stranded, molecules that regulate gene expression through post-transcriptional mechanisms and have the potential to coordinately regulate complex regulatory networks. In this review, we summarize the current knowledge on miRNA alteration/dysregulation in neuropsychiatric disorders, with a special emphasis on schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). With an eye toward the future, we also discuss the diagnostic and prognostic potential of miRNAs for neuropsychiatric disorders in the context of personalized treatments and network medicine. (C) 2016 Elsevier Inc All tights reserved.