Methamphetamine induces oligodendroglial cell death in vitro

Genc K., Genc Ş., Kizildag S., Sonmez Ü., Yilmaz O., Tugyan K., ...Daha Fazla

BRAIN RESEARCH, cilt.982, sa.1, ss.125-130, 2003 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 982 Sayı: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0006-8993(03)02890-7
  • Dergi Adı: BRAIN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.125-130
  • Anahtar Kelimeler: methamphetamine, oligodendrocyte, apoptosis, rat, PROMOTING GENE, APOPTOSIS, NEUROTOXICITY, ABUSE, DP5, BCL-2, BRAIN, LINE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

We investigated whether the psychostimulant methamphetamine (METH) has a cytotoxic effect on oligodendrocytes and which cell-death pathways are involved in the cytotoxic process. METH caused concentration- and time-dependent cytotoxicity in rat oligodendrocyte cultures. METH induced apoptotic cell death and mRNA expression of pro-apoptotic proteins (bax and DP5), but not anti-apoptotic proteins (bcl-2 and bcl-XL). These results suggest that METH induces cytotoxicity in rat oligodendrocytes via the differential regulation of the expression of genes involved in the apoptotic process. (C) 2003 Elsevier B.V. All rights reserved.