THERAPEUTIC EFFECT OF ERYTHROPOIETIN IN AN EXPERIMENTAL IN VIVO ALZHEIMER'S DISEASE ANIMAL MODEL MODERATED BY D-GALACTOSE INJECTION AT OVARIECTOMIZED RATS

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Sahim O., Vurgun U., Yılmaz O., Sönmez A., Dayı A., Yener G., ...Daha Fazla

TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI, cilt.13, sa.3, ss.145-149, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 3
  • Basım Tarihi: 2010
  • Dergi Adı: TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.145-149
  • Anahtar Kelimeler: Alzheimer's Disease; Disease model animal; D-galactose Erythropoietin; Neuroprotection; Apoptosis, CEREBRAL-ISCHEMIA, NERVOUS-SYSTEM, PROTECTS, BRAIN, INJURY, NEURONS, MICE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction: Erythropoietin (Epo) is a molecule which has shown to have neuroprotective effects on animal models of chronic and acute central nervous system disorders like stroke and parkinsonism. Epo shows neuroprotective effect on amiloid beta toxicity in vitro neuronal cell culture. In this study we searched neuroprotective effect of Epo on in vivo animal model of Alzheimer's disease.