Oxidative stress and dysregulated Nrf2 activation in the pathogenesis of schizophrenia

Genc K., GENÇ Ş.

Bioscience Hypotheses, vol.2, no.1, pp.16-18, 2009 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1016/j.bihy.2008.10.005
  • Journal Name: Bioscience Hypotheses
  • Journal Indexes: Scopus
  • Page Numbers: pp.16-18
  • Keywords: ATF4, Brain-derived neurotrophic factor, DISC1, Glycogen synthase kinase-3, Neuroinflammation, Nrf2, Oxidative stress, Schizophrenia
  • Dokuz Eylül University Affiliated: Yes

Abstract

Several processes including oxidative stress and neuroinflammation are implicated in the pathogenesis of schizophrenia. The dysregulated activation of a transcription factor, nuclear factor-E2-related factor-2 (Nrf2) which regulates the expression and coordinated induction of a battery of cytoprotective, antioxidant, and anti-inflammatory genes in response to oxidative stress and inflammation, might play a critical role in the pathogenesis of schizophrenia. © 2008 Elsevier Ltd. All rights reserved.