Oxidative stress and dysregulated Nrf2 activation in the pathogenesis of schizophrenia

Genc K., GENÇ Ş.

Bioscience Hypotheses, cilt.2, sa.1, ss.16-18, 2009 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.bihy.2008.10.005
  • Dergi Adı: Bioscience Hypotheses
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.16-18
  • Anahtar Kelimeler: ATF4, Brain-derived neurotrophic factor, DISC1, Glycogen synthase kinase-3, Neuroinflammation, Nrf2, Oxidative stress, Schizophrenia
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Several processes including oxidative stress and neuroinflammation are implicated in the pathogenesis of schizophrenia. The dysregulated activation of a transcription factor, nuclear factor-E2-related factor-2 (Nrf2) which regulates the expression and coordinated induction of a battery of cytoprotective, antioxidant, and anti-inflammatory genes in response to oxidative stress and inflammation, might play a critical role in the pathogenesis of schizophrenia. © 2008 Elsevier Ltd. All rights reserved.