Proteomic analysis of erythropoietin-induced changes in neuron-like SH-SY5Y cells


Erbayraktar Z., Onkal Z., Genc K. K., GENÇ Ş.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.2, pp.213-221, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1515/tjb-2016-0310
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.213-221
  • Keywords: Erythropoietin, Neuron, Proteomics, Neuroprotection, Drug treatment, Signaling pathways, PYRUVATE-KINASE DEFICIENCY, RECOMBINANT-HUMAN-ERYTHROPOIETIN, IRON OVERLOAD, RECEPTOR, ANEMIA, BRAIN, HYPERTENSION, APOPTOSIS, LOCALIZATION, ISCHEMIA
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Erythropoietin (EPO) is widely used for treatment of anemia associated with different diseases; however, its adverse effects limit its use in clinical practice. Therefore, understanding the effects of EPO at the molecular and cellular level is crucial to adjust treatment regimes, and to develop non-hematopoietic EPO derivatives. In this study, we used a proteomics approach to identify how EPO treatment modifies the cellular proteome.