Proteomic analysis of erythropoietin-induced changes in neuron-like SH-SY5Y cells

Erbayraktar Z., Onkal Z., Genc K. K., GENÇ Ş.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.42, sa.2, ss.213-221, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1515/tjb-2016-0310
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.213-221
  • Anahtar Kelimeler: Erythropoietin, Neuron, Proteomics, Neuroprotection, Drug treatment, Signaling pathways, PYRUVATE-KINASE DEFICIENCY, RECOMBINANT-HUMAN-ERYTHROPOIETIN, IRON OVERLOAD, RECEPTOR, ANEMIA, BRAIN, HYPERTENSION, APOPTOSIS, LOCALIZATION, ISCHEMIA
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Erythropoietin (EPO) is widely used for treatment of anemia associated with different diseases; however, its adverse effects limit its use in clinical practice. Therefore, understanding the effects of EPO at the molecular and cellular level is crucial to adjust treatment regimes, and to develop non-hematopoietic EPO derivatives. In this study, we used a proteomics approach to identify how EPO treatment modifies the cellular proteome.