Inhibitory effects of sulforaphane on NLRP3 inflammasome activation

Kiser C., Gonul C. P., Olcum M., GENÇ Ş.

MOLECULAR IMMUNOLOGY, cilt.140, ss.175-185, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 140
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.molimm.2021.10.014
  • Dergi Adı: MOLECULAR IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.175-185
  • Anahtar Kelimeler: Sulforaphane, Phytochemical, NLRP3 inflammasome, RICH BROCCOLI SPROUTS, ISOTHIOCYANATE, PATHWAY, DAMAGE, NRF2, AUTOPHAGY, DISEASE, INJURY, MICE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

SFN, a dietary phytochemical, is a significant member of isothiocyanates present in cruciferous vegetables at high levels in broccoli. It is a well-known activator of the Nrf2/ARE antioxidant pathway. Long since, the therapeutic effects of SFN have been widely studied in several different diseases. Other than the antioxidant effect, SFN also exhibits an anti-inflammatory effect through suppression of various mechanisms, including inflammasome activation. Considerably, SFN has been demonstrated to inhibit multiple inflammasomes, including NLRP3 inflammasome. NLRP3 inflammasome induces secretion of pro-inflammatory cytokines and promotes inflammatory cell death. The release of pro-inflammatory cytokines enhances the inflammatory response, in turn leading to tissue damage. These self-propelling inflammatory responses would need modulation with exogenous therapeutic agents to suppress them. SFN is a promising candidate molecule for the mitigation of NLRP3 inflammasome activation, which has been related to the pathogenesis of numerous disorders. In this review, we have provided fundamental knowledge about Sulforaphane, elaborated its characteristics, and evidentially focused on its mechanisms of action with regard to its anti-inflammatory, anti-oxidative, and neuroprotective features. Thereafter, we have summarized both in vitro and in vivo studies regarding SFN effect on NLRP3 inflammasome activation.