The Effect of Erythropoietin on Neurotrophic Factors in N9 Murine Microglial Cells

Kuralay F., Cakirli B. B., GENÇ Ş.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.38, sa.6, ss.519-524, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 6
  • Basım Tarihi: 2008
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.519-524
  • Anahtar Kelimeler: Microglia, N9 cell line, murine, erythropoietin, neurotrophic factors, ALZHEIMERS-DISEASE, CEREBRAL-ISCHEMIA, GLIAL-CELLS, ASTROCYTES, EXPRESSION, RECEPTOR, NEURONS, NEUROPROTECTION, MODULATION, MECHANISMS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Aim: In this study, we investigated whether interferon gamma (IFN gamma). lipopolysaccharides (LPS) and amyloid beta (AMY beta), as toxic stimulator agents, and erythropoietin (EPO), as a neurotrophic agent. have an effect on the production of the following neurotrophic factors in the N9 murine microglia cell line: neurotrophin 3 (NT3), neurotrophin 4 (NT4), and brain-derived neurotrophic factor (BDNF).