The Effect of Erythropoietin on Neurotrophic Factors in N9 Murine Microglial Cells

Kuralay F., Cakirli B. B., GENÇ Ş.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.38, no.6, pp.519-524, 2008 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 6
  • Publication Date: 2008
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.519-524
  • Keywords: Microglia, N9 cell line, murine, erythropoietin, neurotrophic factors
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: In this study, we investigated whether interferon gamma (IFN gamma). lipopolysaccharides (LPS) and amyloid beta (AMY beta), as toxic stimulator agents, and erythropoietin (EPO), as a neurotrophic agent. have an effect on the production of the following neurotrophic factors in the N9 murine microglia cell line: neurotrophin 3 (NT3), neurotrophin 4 (NT4), and brain-derived neurotrophic factor (BDNF).