Development of an in vitro Injury Model of Ischemia Reperfusion in Human Brain Microvascular Endothelial Cells and the Evaluation of Cell Injury

ARSLAN N., SAYIN O., ALTUN Z. S., ÇAVDAR Z., YÜKSEL EĞRİLMEZ M., YENER N., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.35, sa.3, ss.195-202, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 3
  • Basım Tarihi: 2010
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.195-202
  • Anahtar Kelimeler: Oxygen glucose deprivation, human brain microvascular endothelial cells, reactive oxygen species, ischemia-reperfusion model, OXYGEN-GLUCOSE DEPRIVATION, HYPOXIA-REOXYGENATION, OXIDATIVE STRESS, EXPRESSION, APOPTOSIS, GENERATION, DAMAGE, DEATH, MECHANISMS, PROTECTS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Aim: In the course of ischemia reperfusion, injury / functional deterioration of the endothelium contribute to tissue damaging process. Hypoxia-reoxygenation model has been used as in vitro model of ischemia reperfusion injury. Oxygen glucose deprivation model can be considered to mimic the in vivo conditions. This study aimed to develop an in vitro model of ischemia reperfusion injury in human brain micro vascular endothelial cells and to evaluate the cell injury caused.