Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production

Genc Ş., Kuralay F., Genc K., Akhisaroglu M., Fadiloglu S., Yorukoglu K., ...Daha Fazla

NEUROSCIENCE LETTERS, cilt.298, sa.2, ss.139-141, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 298 Sayı: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0304-3940(00)01716-x
  • Dergi Adı: NEUROSCIENCE LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.139-141
  • Anahtar Kelimeler: erythropoietin, experimental Parkinsonism, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neuroprotection, nitric oxide, C57/BL, CULTURED RAT ASTROCYTES, BIOLOGICAL-FLUIDS, IN-VIVO, NITRATE, BRAIN
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Erythropoietin (EPO), produced by the kidney and fetal liver, is a cytokine-hormone that stimulates erythropoiesis under hypoxic conditions. It has been shown that EPO is produced in the central nervous system and its receptor is expressed on neurons. Since EPO has neuroprotective effects in vitro and in vivo against brain injury, we investigated the effect of EPO treatment on locomotor activities of animals, survival of nigral dopaminergic neurons and nitrate levels in substantia nigra and striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of Parkinsonism in C57/BL mice. Our findings suggest that EPO has protective and treating effect in MPTP-induced neurotoxicity in this mouse model of Parkinson's Disease via increasing nitric oxide production. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.