Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: A review

Olcum M., Tastan B., Ercan I., Eltutan I. B., GENÇ Ş.

PHYTOMEDICINE, vol.75, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 75
  • Publication Date: 2020
  • Doi Number: 10.1016/j.phymed.2020.153238
  • Journal Name: PHYTOMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Phytochemical, NLRP3 inflammasome, Curcumin, Resveratrol, Sulforaphane, ISCHEMIA/REPERFUSION INJURY, ADIPOSE-TISSUE, RESVERATROL, CURCUMIN, RATS, CELLS, PROTECTS, PATHWAY, SIRT1
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: The NLRP3 inflammasome formation and following cytokine secretion is a crucial step in innate immune responses. Internal and external factors may trigger inflammasome activation and result in inflammatory cytokine secretion. Inflammasome formation and activity play critical roles in several disease pathologies such as cardiovascular, metabolic, renal, digestive, and CNS diseases. Underlying pathways are not yet clear, but phytochemicals as alternative therapies have been extensively used for suppression of inflammatory responses.