How Does Early and Late Reoxygenation Following Hypoxia Affect Human Umbilical Vascular Endothelial Cells in Respect to Oxidative Stress?

ALTUN Z. S., İŞLEKEL G. H., SAYIN O., YÜKSEL EĞRİLMEZ M., GENÇ Ş., Genc K., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.35, no.3, pp.225-229, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2010
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.225-229
  • Keywords: Endothelial cells, hypoxia, early reoxygenation, late reoxygenation, oxidative stress, NITRIC-OXIDE SYNTHASE, GLUCOSE DEPRIVATION, HYPOXIA/REOXYGENATION, EXPRESSION, APOPTOSIS, PROTECTS, OXYGEN
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: Vascular damage induced by hypoxia or hypoxia-reoxygenation has a crucial role in various clinicopathological conditions such as myocardial infarction, renal and cerebral ischemia. Endothelial cells might have a barrier function to vascular damage triggered by diverse stimuli or might be involved in this process. The aim of this study was to evaluate the roles of nitric oxide (NO), nitrotyrosine, endothelial nitric oxide synthase (eNOS), superoxide dismutase (SOD) and malondialdehyde (MDA) in hypoxia and hypoxia-reoxygenation in human vascular endothelial cells in-vitro.