Endothelial Protein C Receptor Expression is Regulated by Sp1 Transcription Factor in Murine Microglia

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Tüfekci K. U., Ateş H., Genç Ş.

The Journal of Basic and Clinical Health Sciences, cilt.5, sa.1, ss.6-13, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.30621/jbachs.854244
  • Dergi Adı: The Journal of Basic and Clinical Health Sciences
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.6-13
  • Anahtar Kelimeler: Microglia, endothelial protein c receptor, lipopolysaccharide, peptidoglycan, Sp1 transcription factor, FACTOR-KAPPA-B, ACTIVATED RECEPTOR-1, ANTICOAGULANT, CELLS, LOCALIZATION, INFLAMMATION, COAGULATION, ENDOTOXEMIA, PROTECTION, APOPTOSIS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objectives: Microglial cells are the central regulators of inflammatory responses in the brain and spinal cord. In addition to surveillance during resting state, they become activated due to microbial molecules and pathological insults. Endogenously expressed Activated protein C (APC) is an anticoagulant molecule with anti-inflammatory and cytoprotective roles, mediated by one of its receptors, Endothelial protein C receptor (EPCR). This study aimed to examine the basal and inducible expression of EPCR and unravel the regulatory mediators of its expression in microglia.