Doç. Dr. MELTEM ALPER

Yayın Ağı

Makaleler 25

1. TNF-α orchestrates ADAM metallopeptidase with thrombospondin type 1 motif 2 upregulation and extracellular matrix remodeling through multimodal signaling in osteosarcoma cells

Aymaz E. M., ALPER M., Kalfa Y., Kockar F.

Molecular Biology Reports , cilt.53, sa.1, 2026 (SCI-Expanded, Scopus)

2. Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF-κB and STAT3 pathways in osteosarcoma

Aymaz E. M., ALPER M., Sav F. N., Aydemir T., Kockar F.

JOURNAL OF CELL COMMUNICATION AND SIGNALING , cilt.20, sa.2, 2026 (SCI-Expanded, Scopus)

3. SP1 as a negative regulator of ADAMTS-8 in colorectal cancer: Evidence from functional and molecular analyses

KALFA Y., SAV F. N., ALPER M., KOCKAR F.

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , cilt.1869, sa.1, 2026 (SCI-Expanded, Scopus)

4. TNF-α-Induced Upregulation of ADAMTS-8 Expression in SW480 Cells: Implications for Intracellular Signaling Pathways and Transcription Factor Activity

ALPER M., KALFA Y., SAV F. N., EROĞLU K. P., KÖÇKAR F.

Cell Biochemistry and Biophysics , cilt.84, sa.1, ss.927-942, 2026 (SCI-Expanded, Scopus)

5. The role of thrombin in the paradoxical interplay of cancer metastasis and the vascular system: A driving dynamic

Bayrak O., ALPER M., BAŞBINAR Y., BAYRAK S.

Biomedicine and Pharmacotherapy , cilt.186, 2025 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

6. STAT-3, ELK-1, and c- Jun contributes IL-6 mediated ADAMTS-8 upregulation in colorectal cancer

Alper M., Sav F. N., Keleş Y., Paspal Eroğlu K., Keskin S. D., Köçkar F.

MOLECULAR BIOLOGY REPORTS , cilt.52, ss.246-258, 2025 (SCI-Expanded, Scopus)

7. C/EBPα Mediated Transcriptional Regulation of Human ADAMTS-3 Gene and Collagen Expression in Osteosarcoma Cells

Alper M., Aydemir T., Köçkar F.

Adıyaman Üniversitesi Fen Bilimleri Dergisi , cilt.14, sa.2, 2024 (TRDizin)

8. Effect of Collagen-Coating Variations on the Morphology and Viability of Human Vascular Smooth Muscle Cells

Bayrak Ö., Çalıbaşı Koçal G., Başbınar Y., Alper M., Bayrak S.

Journal of Basic and Clinical Health Sciences , cilt.8, sa.3, ss.726-733, 2024 (TRDizin) Sürdürülebilir Kalkınma

9. TGF-β1 Transactivates ADAMTS-2 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif 2) in Saos-2 Cells through Canonical and Non-Canonical Pathways

Alper M.

CYTOLOGY AND GENETICS , cilt.57, sa.3, ss.282-289, 2023 (SCI-Expanded, Scopus)

10. Hypoxic regulation of ADAMTS-2 and-3 (a disintegrin and matrix metalloproteinase with thrombospondin motifs 2 and 3) procollagen N proteinases by HIF-1 alpha in endothelial cells

Altuntas C., ALPER M., Keles Y., Sav F. N., KÖÇKAR F.

MOLECULAR AND CELLULAR BIOCHEMISTRY , cilt.478, 2023 (SCI-Expanded, Scopus)

11. Expression Pattern of ADAMTS-3 (A Disintegrin and Matrix Metalloproteinase Type,1 Motif 3) in Normal and Cancer Cell Lines

Alper M., Aydemir A., Köçkar F.

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi , cilt.13, sa.1, ss.40-47, 2022 (TRDizin) Sürdürülebilir Kalkınma

12. USF1 Suppresses Expression of Fibrillar Type I, II, and III Collagen and pNP Adamts-3 in Osteosarcoma Cells

Alper M., Aydemir T., Kockar F.

MOLECULAR BIOLOGY , cilt.55, sa.4, ss.580-588, 2021 (SCI-Expanded, Scopus)

13. Effect of Angiogenesis Related Growth Factors VEGF-a and FGF-1 on Osteosarcoma Cell Proliferation

ALPER M.

Adıyaman Üniversitesi Fen Bilimleri Dergisi , cilt.10, sa.2, ss.403-412, 2020 (Scopus, TRDizin)

14. Molecular cloning and biochemical characterization of a Tau class glutathione S-transferase from Pinus brutia Ten

Alper M., Oztetik E., Kaya M. Y., Kockar F.

TREES-STRUCTURE AND FUNCTION , cilt.34, sa.3, ss.835-843, 2020 (SCI-Expanded, Scopus)

15. SP1-mediated downregulation of ADAMTS3 gene expression in osteosarcoma models

Aydemir A. T., Alper M., Kockar F.

GENE , cilt.659, ss.1-10, 2018 (SCI-Expanded, Scopus)

16. Amplification of GC-rich ADAMTS-2 and URG4/URGCP promoter regions with optimized combination of PCR enhancers

Alper M., Tokay E., Kockar F.

TURKISH JOURNAL OF BIOLOGY , cilt.40, sa.1, ss.196-205, 2016 (SCI-Expanded, Scopus, TRDizin)

17. Induction of human ADAMTS-2 gene expression by IL-1 alpha is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells

Alper M., Aydemir A. T., Kockar F.

GENE , cilt.573, sa.2, ss.321-327, 2015 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

18. Molecular characterization of zeta class glutathione S-transferases from Pinus brutia Ten.

Oztetik E., Kockar F., Alper M., Iscan M.

JOURNAL OF GENETICS , cilt.94, sa.3, ss.417-423, 2015 (SCI-Expanded, Scopus)

19. IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) in human osteosarcoma cells mediated by JNK pathway

Alper M., Kockar F.

MOLECULAR AND CELLULAR BIOCHEMISTRY , cilt.393, sa.1-2, ss.165-175, 2014 (SCI-Expanded, Scopus)

20. Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: Influences on the catalytic activity and affinity for inhibitors

Turkoglu S., Maresca A., Alper M., Kockar F., Isik S., Sinan S., et al.

BIOORGANIC & MEDICINAL CHEMISTRY , cilt.20, sa.7, ss.2208-2213, 2012 (SCI-Expanded, Scopus)

21. Evaluation of in vitro effects of some analgesic drugs on erythrocyte and recombinant carbonic anhydrase I and II

Gokce B., Gencer N., Arslan O., Turkoglu S. A., Alper M., Kockar F.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , cilt.27, sa.1, ss.37-42, 2012 (SCI-Expanded, Scopus)

22. Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors

Kockar F., Maresca A., Aydin M., Isik S., Turkoglu S., Sinan S., et al.

BIOORGANIC & MEDICINAL CHEMISTRY , cilt.18, sa.15, ss.5498-5503, 2010 (SCI-Expanded, Scopus)

23. Saccharomyces cerevisiae beta-Carbonic Anhydrase: Inhibition and Activation Studies

Isik S., Guler O. O., Kockar F., Aydin M., Arslan O., Supuran C. T.

CURRENT PHARMACEUTICAL DESIGN , cilt.16, sa.29, ss.3327-3336, 2010 (SCI-Expanded, Scopus)

24. Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids

Isik S., Kockar F., Aydin M., Arslan O., Guler O. O., Innocenti A., et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , cilt.19, sa.6, ss.1662-1665, 2009 (SCI-Expanded, Scopus)

25. Carbonic anhydrase inhibitors: Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates

Isik S., Kockar F., Aydin M., Arslan O., Guler O. O., Innocenti A., et al.

BIOORGANIC & MEDICINAL CHEMISTRY , cilt.17, sa.3, ss.1158-1163, 2009 (SCI-Expanded, Scopus)

Hakemli Bilimsel Toplantılarda Yayımlanmış Bildiriler 41

1. Functional role of MATN3 in osteosarcoma cell growth and motility

ÖCAL F., CAN S., ALPER M.

8th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2025), Ankara, Türkiye, 17 - 19 Aralık 2025, ss.187, (Özet Bildiri)

2. Targeting UHRF2 (Ubiquitin-like with PHD and ring finger domains 2) in osteosarcoma: Impacts on proliferation and emt dynamics

CAN S., ÖCAL F., ALPER M.

8th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2025), Ankara, Türkiye, 17 - 19 Aralık 2025, ss.188, (Özet Bildiri)

3. Modulation of the E3 ubiquitin ligase UHRF2 (ubiquitin like with PHD and ring finger domains 2) by low oxygen conditions in tumor cells

ÖCAL F., CAN S., ALPER M.

49th FEBS Congress, Bridging Continents to Advance Life Science, İstanbul, Türkiye, 5 - 09 Temmuz 2025, cilt.15, ss.130, (Özet Bildiri)

4. Hypoxia-driven changes in MATN3 expression and EMT associated marker profiles in osteosarcoma

ÖCAL F., CAN S., ALPER M.

49th FEBS Congress, Bridging Continents to Advance Life Science, İstanbul, Türkiye, 5 - 09 Temmuz 2025, cilt.15, ss.129-130, (Özet Bildiri)

5. FGF-induced downregulation of ADAMTS-8 mRNA in Saos-2 cells

ALPER M., KÖÇKAR F.

9th International Congress of the Molecular Biology Association of Turkey, İzmir, Türkiye, 12 - 14 Eylül 2024, ss.184, (Özet Bildiri)

6. VEGF-A upregulates ADAMTS-8 expression in SW480 cells

SAV F. N., ALPER M., KELEŞ Y., KÖÇKAR F.

9th International Congress of the Molecular Biology Association of Turkey, İzmir, Türkiye, 12 - 14 Eylül 2024, ss.177, (Özet Bildiri)

7. SP1-mediated Up-regulation of MIR100HG in Hepatocellular Carcinoma

KÖÇKAR F., AVŞAR KOÇ Ş., TÜRKOĞLU A., ALAÇAM R., TOKAY E., ALPER M., et al.

9th International Congress of the Molecular Biology Association of Turkey, İzmir, Türkiye, 12 - 14 Eylül 2024, ss.34, (Özet Bildiri)

8. TGF-β1 Induces ADAMTS8 (A Disintegrin and Metalloproteinase with Thrombospondin Motif 8) Expression in MG-63 Cells.

Alper M.

International Eurasian Conference on Biotechnology and Biochemistry, Ankara, Türkiye, 16 - 18 Aralık 2020, ss.162, (Özet Bildiri)

9. EGF (Epidermal Growth Factor) Suppresses ADAMTS-8 (A disintegrin and metalloproteinase with thrombospondin motif, 8) mRNA Expression in Saos-2 and MG-63 Osteosarcoma Models.

Alper M.

9th INTERNATIONAL MOLECULAR BIOLOGY AND BIOTECHNOLOGY CONGRESS, Kars, Türkiye, 6 - 10 Aralık 2020, ss.39, (Özet Bildiri)

10. Molecular cloning and sequence analysis of human ADAMTS-8 (A disintegrin and metalloproteinase with thrombospondin motif, 8) gene promoter.

Alper M., Keskin S. D., Köçkar F.

3 rd International Eurasian Conference on Biological and Chemical Sciences (, Ankara, Türkiye, 19 - 20 Mart 2020, ss.345, (Özet Bildiri)

11. USF Mediated Regulation of Human A Disintegrin and Metalloproteinase with Thrombospondin Type 1, Motif 3 (ADAMTS-3) Gene Expression in Osteosarcoma

Alper M., Aydemir A. T., Köçkar F.

International Science and Academic Congress, Konya, Türkiye, 19 - 20 Nisan 2019, ss.42-43, (Özet Bildiri)

12. TNF-α Mediated Upregulation of the Human ADAMT S-3 Gene Expression in Osteoblast -like Cells

ALPER M., Aymaz E. M., AYDEMIR A. T., KÖÇKAR F.

6th International Molecular Biology and Biotechnology Congress, Afyon, Türkiye, 22 - 25 Aralık 2017, ss.18, (Özet Bildiri)

13. TNF-a Mediated Upregulation of the human ADAMTS-3 Gene Expression in osteoblast-like cells.

Alper M., Aymaz E. M., Aydemir A. T., Köçkar F.

’ 6th International Molecular Biology and Biotechnology Congress, Afyonkarahisar, Türkiye, 22 - 25 Aralık 2017, ss.18, (Özet Bildiri)

14. Transactivation of the human ADAMTS-2 gene promoter through proinflammatory cytokine TNF-a in osteoblast-like cells

Alper M., Aydemir T., Köçkar F.

40th FEBS Congress, Berlin, Almanya, 4 - 09 Temmuz 2015, cilt.282, ss.82, (Özet Bildiri)

15. TNFα Differentially Regulate Human ADAMTS-3 Promoter Activity in Osteosarcoma Cells

Aydemir A., Alper M., Köçkar F.

EACR-Sponsored 3rd Anticancer Agent Development Congress, İzmir, Türkiye, 18 - 19 Mayıs 2015, ss.179, (Özet Bildiri)

16. Up-regulation of Human ADAMTS-2 via IL-6 in Osteosarcoma Cells

Alper M., Köçkar F.

III. Uluslararası Moleküler Biyoloji Kongresi, İzmir, Türkiye, 10 - 12 Eylül 2014, ss.229, (Özet Bildiri)

17. Functional Analysis of the Human ADAMTS-3 Gene Promoter

Aydemir A. T., Alper M., Köçkar F.

III. International Congress of the Molecular Biology Assoc, İzmir, Türkiye, 10 - 12 Eylül 2014, ss.177, (Özet Bildiri)

18. Molecular cloning and in silico analysis of human ADAMTS-3 (a disintegrin and metalloprotease with thrombospondin motifs) gene promoter

Alper M., Aydemir A., Köçkar F.

FEBS EMBO 2014, Paris, Fransa, 30 Ağustos - 04 Eylül 2014, cilt.281, ss.253-254, (Özet Bildiri)

19. İnsan ADAMTS-2 (A Disintegrin and Metalloprotease Domain with Thrombospondin Type I Motif II) Geninin Transkripsiyonel Regülasyonu

Alper M., Köçkar F.

22. Ulusal Biyoloji Kongresi, Eskişehir, Türkiye, 23 - 27 Haziran 2014, ss.304, (Özet Bildiri)

20. IL-1α (İnterlökin 1α) Sitokininin İnsan ADAMTS-3 (A Disintegrin and Metalloprotease Domain with Thrombospondin Type I Motif III) Ekspresyonuna Olan Etkisinin Belirlenmes

Aydemir A., Alper M., Köçkar F.

22. Ulusal Biyoloji Kongresi, Eskişehir, Türkiye, 23 - 27 Haziran 2014, ss.294, (Özet Bildiri)

21. IL 1 ( İnterlökin 1) Sitokininin İnsan ADAMTS 3 A Disintegrin and Metalloprotease Domain with Thrombospondin Type I Motif III Ekspresyonuna Olan Etkisinin Belirlenmesi

AYDEMIR A. T., ALPER M., KÖÇKAR F.

22. Ulusal Biyoloji Kongresi 23-27 Haziran 2014, Eskişehir, Türkiye, Eskişehir, Türkiye, 23 Haziran 2014, ss.294, (Özet Bildiri)

22. İnsan SMAD4 Geninin Ökaryotik Ekspresyon Vektörüne Klonlanması

Gültekin A. S., Güler G., Alper M., Köçkar F.

22. Ulusal Biyoloji Kongresi, Eskişehir, Türkiye, 23 - 27 Haziran 2014, ss.1237, (Özet Bildiri)

23. Rekombinant Pinus brutia Ten. Glutathione-S transferase Tau Enziminin Ekspresyonu ve Karakterizasyonu

Alper M., Kaya M. Y., Öztetik E., Köçkar F.

II.Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi, Antalya, Türkiye, 15 - 18 Kasım 2012, ss.35, (Özet Bildiri)

24. İnsan Smad3 Geninin Farklı Hücre Hatlarındaki Ekspresyon Analizi ve Klonlanması

Güler G., Alper M., Köçkar F.

II.Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi, Antalya, Türkiye, 15 - 18 Kasım 2012, ss.149, (Özet Bildiri)

25. Effects of fibroblast growth factor (FGF acidic) and epidermal growth factor (EGF) on procollagen-N proteinases; ADAMTS-2 and ADAMTS-3 in osteosarcoma model

Alper M., Kockar F.

22nd IUBMB Congress/37th FEBS Congress, Sevilla, İspanya, 4 - 09 Eylül 2012, cilt.279, ss.494, (Özet Bildiri)

26. Cloning of human ADAMTS-2 Promoter: Strategies for cloning extremely GC rich promoters

Alper M., Kockar F.

36th FEBS Congress of the Biochemistry for Tomorrows Medicine, Torino, İtalya, 25 - 30 Haziran 2011, cilt.278, ss.74, (Özet Bildiri)

27. Expression analysis of URG4 (upregulated gene 4) in osteoblast-like cells, Saos-2 and MG63

Kockar F., Tokay E., Alper M.

36th FEBS Congress of the Biochemistry for Tomorrows Medicine, Torino, İtalya, 25 - 30 Haziran 2011, cilt.278, ss.213, (Özet Bildiri)

28. Kollajen Metabolizmasında Anahtar ADAMTS-2 Geninin Hep3B, MCF7, HT-29, PC3 ve DU145 Hücre Hatlarındaki Ekspresyonu

Alper M., Köçkar F.

I.Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi , Antalya, Türkiye, 26 - 29 Ekim 2010, ss.32, (Özet Bildiri)

29. MCF-7 Hücre Hattında URG4(UpRegulated Gene 4) Geninin Ekspresyon Analizi

Tokay E., Alper M., Köçkar F.

I.Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi , Antalya, Türkiye, 26 - 29 Ekim 2010, ss.20, (Özet Bildiri)

30. The effects of some neuroleptic drugs on Paraoxonase enzyme activity purified from human serum and in Hep3B cells

Avcikurt A., Aydin M., Demir D., Yildirim H., Eryilmaz S., Turkoglu S. A., et al.

34th Congress of the Federation-of-European-Biochemical-Societies, Prague, Çek Cumhuriyeti, 4 - 09 Temmuz 2009, cilt.276, ss.299-300, (Özet Bildiri)

31. Phylogenetic and bioinformatic analysis of Glutathione S-Transferase Tau from Pinus brutia

Oztetik E., Aydin M., Kockar F.

34th Congress of the Federation-of-European-Biochemical-Societies, Prague, Çek Cumhuriyeti, 4 - 09 Temmuz 2009, cilt.276, ss.116, (Özet Bildiri)

32. Is there any antitumor effects of oleuropein in different tumour types: Breast, Prostate and Hepatoma models?

Alper M., Aydogan Türkoğlu S., Köçkar F.

4th EORTC Pathobiology Group Annual Meeting & 1st International Multidisciplinary Cancer Research Congress, Antalya, Türkiye, 21 - 24 Mayıs 2009, (Özet Bildiri)