Induction of human ADAMTS-2 gene expression by IL-1 alpha is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells

Alper M., Aydemir A. T., Kockar F.

GENE, cilt.573, sa.2, ss.321-327, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 573 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.gene.2015.07.064
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.321-327
  • Anahtar Kelimeler: ADAMTS-2, ADAMTS-3, IL-1 alpha, Saos-2, MG-63, MEK/JNK/PI3K, HUMAN OSTEOSARCOMA CELLS, FACTOR-KAPPA-B, ARTICULAR-CARTILAGE, MATRIX METALLOPROTEINASES, THROMBOSPONDIN MOTIFS, HUMAN CHONDROCYTES, IN-VITRO, OSTEOARTHRITIS, ARTHRITIS, DISINTEGRIN
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Up-regulation of ADAMTS genes with proinflammatory cytokines is important for some pathological conditions such as osteoarthritis (OA) that is a disease based on ECM degradation in cartilage. IL-1 alpha is a proinflammatory cytokine and important both to normal and pathophysiologic conditions in cartilage and bone. Effects of some proinflammatory cytokines such as TNF-alpha and IL-1 beta on the some members of ADAMTS family have been investigated in some chondrocyte tissues or cell lines. However the effect of the IL-1 alpha on the expression of ADAMTS-2 and ADAMTS-3 gene expression in osteoblast like cell lines, remains unclear. Therefore, the aim of this study is to investigate the effect of IL-1 alpha on ADAMTS-2 and ADAMTS-3 gene expression in osteoblast like cells, Saos-2 and MG-63.