Dr. Öğr. Üyesi SİBEL KALYONCU UZUNLAR

Yayın Ağı

Makaleler 25

1. Novel anti-VEGF scFv antibodies with superior in vitro and in vivo activities

ÇAKAN AKDOĞAN G., Erez O., Ozer C., Onal E., Mert O., Gullu S., et al.

Scientific Reports , cilt.15, sa.1, 2025 (SCI-Expanded)

2. Deglycosylation of VEGF Produced in Pichia pastoris Reduces its in Vitro Binding and Angiogenic Effect

KALYONCU UZUNLAR S., Ozer-Cokgezme C., Arslan M., Kurden-Pekmezci A., Erez O., ÇAKAN AKDOĞAN G., et al.

Biotechnology Journal , cilt.20, sa.11, 2025 (SCI-Expanded, Scopus)

3. Cell line development and bioreactor process optimization for an atezolizumab biosimilar

Kuyucu A. Z., Sayili D., Orkut R., Mert O., Tarman İ. O., Lulaci B., et al.

Biotechnology and Applied Biochemistry , cilt.72, sa.4, ss.897-910, 2025 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

4. Development of a Recombinant Omicron BA.1 Subunit Vaccine Candidate in Pichia pastoris

Kalyoncu S., Sayili D., Kuyucu A. Z., Soyturk H., Gullu S., Ersayan B., et al.

MICROBIAL BIOTECHNOLOGY , cilt.18, sa.1, 2025 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

5. Biomarkers of NRF2 signalling: Current status and future challenges

Morgenstern C., Lastres-Becker I., Demirdöğen B. C., Costa V. M., Daiber A., Foresti R., et al.

Redox Biology , cilt.72, 2024 (SCI-Expanded, Scopus)

6. Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris

Kalyoncu S., Yilmaz S., Kuyucu A. Z., Sayili D., Mert O., Soyturk H., et al.

SCIENTIFIC REPORTS , cilt.13, sa.1, 2023 (SCI-Expanded, Scopus)

7. Engineering of conserved residues near antibody heavy chain complementary determining region 3 (HCDR3) improves both affinity and stability

Arslan M., Uluçay T., Kale S., Kalyoncu S.

Biochimica et Biophysica Acta - Proteins and Proteomics , cilt.1871, sa.4, 2023 (SCI-Expanded, Scopus)

8. Physicochemical differences between camelid single-domain antibodies and mammalian antibodies

Eskier N. E., Eskier D., FİRUZAN E., KALYONCU UZUNLAR S.

Turkish Journal of Biology , cilt.47, sa.6, ss.423-436, 2023 (SCI-Expanded, Scopus, TRDizin)

9. Omicron variants bind to human angiotensin-converting enzyme 2 (ACE2) much stronger due to higher number of charged-charged interactions

KALYONCU UZUNLAR S.

Biotech Studies , cilt.32, sa.2, ss.75-82, 2023 (Scopus)

10. Effect of non-repetitive linker on in vitro and in vivo properties of an anti-VEGF scFv

Arslan M., Karadag M., Onal E., Gelinci E., ÇAKAN AKDOĞAN G., Kalyoncu S.

SCIENTIFIC REPORTS , cilt.12, sa.1, 2022 (SCI-Expanded, Scopus)

11. Roles of matrix metalloproteinases in the cornea: A special focus on macular corneal dystrophy

Kaya S. G., Inanc-Surer S., ÇAKAN AKDOĞAN G., OKTAY G., Utine C. A., Kalyoncu S.

Medicine in Drug Discovery , cilt.11, 2021 (Scopus)

12. CENP-A Nucleosome is a Sensitive Allosteric Scaffold for DNA and Chromatin Factors

Dogan D., Arslan M., Ulucay T., Kalyoncu S., Dimitrov S., Kale S.

JOURNAL OF MOLECULAR BIOLOGY , cilt.433, sa.6, 2021 (SCI-Expanded, Scopus)

13. Directed evolution of conformation-specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations

Lou W., Stimple S. D., Desai A. A., Makowski E. K., KALYONCU UZUNLAR S., Mogensen J. E., et al.

BIOTECHNOLOGY AND BIOENGINEERING , cilt.118, sa.2, ss.797-808, 2021 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

14. Conformational changes in a Vernier zone region: Implications for antibody dual specificity

Arslan M., Karadag D., Kalyoncu S.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS , cilt.88, sa.11, ss.1447-1457, 2020 (SCI-Expanded, Scopus)

15. Physicochemical determinants of antibody-protein interactions

Karadag M., Arslan M., Kaleli N. E., Kalyoncu S.

ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 121 , cilt.121, ss.85-114, 2020 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

16. Sensitive detection of glucagon aggregation using amyloid fibril-specific antibodies

Stimple S. D., KALYONCU UZUNLAR S., Desai A. A., Mogensen J. E., Spang L. T., Asgreen D. J., et al.

BIOTECHNOLOGY AND BIOENGINEERING , cilt.116, sa.8, ss.1868-1877, 2019 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

17. Phage display derived therapeutic antibodies have enriched aliphatic content: Insights for developability issues

Kaleli N. E., Karadag M., Kalyoncu S.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS , cilt.87, sa.7, ss.607-618, 2019 (SCI-Expanded, Scopus)

18. Protein engineering approaches for antibody fragments: directed evolution and rational design approaches

Arslan M., Karadag D., Kalyoncu S.

TURKISH JOURNAL OF BIOLOGY , cilt.43, sa.1, ss.1-12, 2019 (SCI-Expanded, Scopus, TRDizin)

19. **Both positional and chemical variables control in vitro proteolytic cleavage of a presenilin ortholog**

Naing S., KALYONCU UZUNLAR S., Smalley D. M., Kim H., Tao X., George J. B., et al.

JOURNAL OF BIOLOGICAL CHEMISTRY , cilt.293, sa.13, ss.4653-4663, 2018 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

20. Enzymatic hydrolysis by transition-metal-dependent nucleophilic aromatic substitution

KALYONCU UZUNLAR S., Heaner D. P., Kurt Z., Bethel C. M., Ukachukwu C. U., Chakravarthy S., et al.

NATURE CHEMICAL BIOLOGY , cilt.12, sa.12, ss.1031-1039, 2016 (SCI-Expanded, Scopus)

21. Lessons from an α-Helical Membrane Enzyme: Expression, Purification, and Detergent Optimization for Biophysical and Structural Characterization

Johnson J. L., KALYONCU UZUNLAR S., Lieberman R. L.

HETEROLOGOUS EXPRESSION OF MEMBRANE PROTEINS: METHODS AND PROTOCOLS, 2ND EDITION , cilt.1432, ss.281-301, 2016 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

22. Catalytic Properties of lntramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay

Naing S., Vukoti K. M., Drury J. E., Johnson J. L., KALYONCU UZUNLAR S., Hill S. E., et al.

ACS CHEMICAL BIOLOGY , cilt.10, sa.9, ss.2166-2174, 2015 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

23. Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization

Johnson J. L., Entzminger K. C., Hyun J., KALYONCU UZUNLAR S., Heaner D. P., Morales I. A., et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY , cilt.71, ss.896-906, 2015 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

24. Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments

KALYONCU UZUNLAR S., Hyun J., Pai J. C., Johnson J. L., Entzminger K., Jain A., et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS , cilt.82, sa.9, ss.1884-1895, 2014 (SCI-Expanded, Scopus)

25. Interaction prediction and classification of PDZ domains

KALYONCU UZUNLAR S., Keskin O., Gursoy A.

BMC BIOINFORMATICS , cilt.11, 2010 (SCI-Expanded, Scopus)

Hakemli Bilimsel Toplantılarda Yayımlanmış Bildiriler 6

1. Leveraging single B cell technologies in the development of anti-PD-L1 antibodies

Sencer A. M., GÜNGÖR B., Kurden-Pekmezci A., Sayili D., Kuyucu A. Z., Ozgenc S., et al.

7th European Conference of Immunology, Dublin, İrlanda, 1 - 04 Eylül 2024, cilt.54, ss.766, (Özet Bildiri)

2. A zebrafish model of macular cornea dystrophy provides the first preclinical test model

Esra E. G., BAŞOL M., Gelinci E., KALYONCU UZUNLAR S., YILDIRIM C. A., ÇAKAN AKDOĞAN G.

ESGCT 30th Annual Congress, Brüksel, Belçika, 24 Ekim 2023, (Özet Bildiri)

3. MAKÜLER KORNEA DİSTROFİSİNİN TEDAVİSİNDE KULLANILMAK ÜZERE MMP-1 VE MMP-13’xxÜN REKOMBİNANT ÜRETİMİ

kaya s. g., ÇOBAN H. B., YILDIRIM C. A., kalyoncu S.

V. Türkiye in Vitro Diyagnostik Sempozyumu: Sağlık Biyoteknolojisi, Türkiye, 19 - 21 Şubat 2020, (Özet Bildiri)

4. Directed evolution of antibodies with high conformational specificity for glucagon amyloid fibrils

Stimple S., Kalyoncu S., Desai A., Mogensen J., Spang L., Asgreen D., et al.

257th National Meeting of the American-Chemical-Society (ACS), Florida, Amerika Birleşik Devletleri, 31 Mart - 04 Nisan 2019, cilt.257, (Özet Bildiri)

5. The Use of Engineered Antibody Fragments to Promote Crystallization of Membrane Proteins

KALYONCU UZUNLAR S., Johnson J. L., Heaner D. P., Morales I. A., Hyun J., Pai J. C., et al.

58th Annual Meeting of the Biophysical-Society, San-Francisco, Kostarika, 15 - 19 Şubat 2014, cilt.106, (Özet Bildiri)

6. Interaction prediction of PDZ domains using a machine learning approach

KALYONCU UZUNLAR S., Keskin O., Gursoy A.

2010 5th International Symposium on Health Informatics and Bioinformatics, HIBIT 2010, Antalya, Türkiye, 20 - 22 Nisan 2010, ss.121-124, (Tam Metin Bildiri)

Kitaplar 2

1. KODON OPTİMİZASYONU VE REKOMBİNANT PROTEİN ÜRETİMİNDEKİ YERİ

Arslan M., Kaleli N. E., Karadağ M., Yarımçam M. C., KALYONCU UZUNLAR S., ALOTAİBİ H.

PROTEİN: YAPISI, MÜHENDİSLİĞİ, ETKİLEŞİMLERİ, DİNAMİĞİ VE İLAÇ TASARIMINDAKİ YERİ, SALİHA ECE ACUNER, Editör, Ankara Nobel Tıp Kitabevleri, Ankara, ss.115-134, 2021

2. Lessons from an α-Helical Membrane Enzyme: Expression, Purification, and Detergent Optimization for Biophysical and Structural Characterization

Johnson J., KALYONCU UZUNLAR S., Lieberman R.

Heterologous Expression of Membrane Proteins: Methods and Protocols, , Editör, Springer New York, ss.281-301, 2016

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271

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240

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3908

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