Akademik Veri Yönetim Sistemi
Toxicology Oxidative Stress and Dietary Antioxidants, Preedy VR.,Patel VB, Editör, Elsevier Science, Oxford/Amsterdam , London, ss.447-456, 2021
Alpha amanitin (α-AMA) is a toxin with hepatotoxic and nephrotoxic effects found in the content of Amanita phalloides-type mushrooms, causing serious poisoning with fatal outcomes. In the mechanism of toxicity, inhibition of protein synthesis by blocking RNA polymerase II in the liver plays an important role as well as oxidative stress and inflammation. Development of α-AMA-induced oxidative stress in the liver and kidney tissues was verified by increased superoxide dismutase activity, decreased catalase activity, increased malondialdehyde activity, and protein carbonylation. Silibinin and N-acetylcysteine used in the treatment of poisoning with mushrooms containing α-AMA have strong antioxidant effects. Resveratrol, Ganoderma lucidum, and polymyxin B were also found to be effective in reversing the toxicity induced by α-AMA in the experimental studies. The high mortality rate of poisoning with α-AMA containing mushrooms despite the treatment shows the necessity of developing new treatment alternatives. Therefore, it is important to develop antidotes that both prevent the uptake of the toxin into the liver cell and have a strong antioxidant effect.