Production, Characterization and Electrochemical Sensor Applications of Metal Oxide Nanostructure

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Tezin Türü: Doktora

Tezin Yürütüldüğü Kurum: Dokuz Eylül Üniversitesi, Fen Bilimleri Enstitüsü, Türkiye

Tezin Onay Tarihi: 2024

Tezin Dili: İngilizce

Öğrenci: TÜLAY KOÇ DELİCE

Danışman: Necmiye Funda Ak Azem

Özet:

The thesis study aims to use metal oxide nanostructures in the detection of salbutamol sulphate analyte and to develop materials for electrochemical sensor applications. The study consists of two main parts. In the first part, we conducted the synthesis and characterization of copper oxide (CuO) and tin oxide (SnO₂) nanoparticles doped with transition metal, manganese (Mn), and rare earth element, cerium (Ce), using the sol-gel method. The effects of sol-gel parameters on nanoparticle structure, size, and morphology were investigated. In the second part, a carbon paste electrode for salbutamol (SAL) detection was prepared and modified with synthesized nanoparticles. The undoped and doped CuO nanoparticles with Mn or Ce dopants showed the highest sensitivity and lowest detection limits. The sensor developed with Mn doped CuO nanoparticles (CuO-Mn2) detected SAL from 2 µM to 200 µM, and the limit of detection (LOD) was 58.25 nM. The correlation value of the sensor generated with Ce-doped CuO was 0.9929, the LOD was 34.18 nM, and the LOQ was 113.95 nM. The sensor, which was built using undoped SnO₂ nanoparticles, was found to be ineffective in detecting SAL. In this case, the sensor properties were improved by doping SnO₂ nanoparticles with transition metals and rare earth elements.  Mn and Ce doped SnO₂ sensors showed LOD values of 56.84 nM and 3.16 nM, respectively, and the correlation values for SAL were calculated as 0.9995 between 5 µM and 100 µM and 0.9905 between 2 µM and 100 µM. These findings indicate that using additives in carbon paste electrodes improved sensitivity and lower detection limits for analyte detection. It was determined that the amount and type of additives used, as well as the nanostructured metal oxide component, significantly affected the sensor's electrochemical performance