The association between birth weight and the risk of neuroblastoma: a meta-analysis of observational studies involving 4,361,141 participants

Olgun, HATİCE; Arayici, Mehmet; Çeçen, REFİK; Başbınar, YASEMİN; Ellidokuz, HÜLYA

doi:10.21203/rs.3.rs-2483109/v1

The association between birth weight and the risk of neuroblastoma: a meta-analysis of observational studies involving 4,361,141 participants

Atıf İçin Kopyala

Olgun H. N., Arayici M. E., Çeçen R. E., Başbınar Y., Ellidokuz H.

AMERICAN JOURNAL OF CANCER RESEARCH, cilt.13, sa.9, ss.3854-3863, 2023 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 13 Sayı: 9
Basım Tarihi: 2023
Doi Numarası: 10.21203/rs.3.rs-2483109/v1
Dergi Adı: AMERICAN JOURNAL OF CANCER RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, EMBASE
Sayfa Sayıları: ss.3854-3863
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Abstract: One of the most common extracranial solid tumors in childhood is neuroblastoma. In this study, it was aimed to perform a systematic review and meta-analysis to evaluate the risk of neuroblastoma in both high and low birth weights. The PRISMA and MOOSE guidelines were followed during the design, analysis, and reporting of this study. A comprehensive literature search was undertaken for the published papers in Embase, PubMed/Medline, Scopus, and the Web of Science (WoS) databases. The odds ratio (OR) of neuroblastoma in high and low birth weight groups, with 95% confidence intervals (CIs), were calculated using the random-effects and fixed-effects models. A total of 16 papers and 4,361,141 participants were included in this study. When the random-effects model and the fixed-effects model were used, high birth weight was associated with an increased risk of neuroblastoma (OR = 1.17; 95% CI: 1.06-1.29, P = 0.002; heterogeneity: Chi2 = 2.33, df = 15, I2 = 0%, P>0.05). Similarly, it was observed that individuals with low birth weights may also face an increased risk of developing neuroblastoma later in life (OR = 1.19; 95% CI: 1.03-1.37, P = 0.017; heterogeneity: Chi2 = 16.93, df = 15, I2 = 0%, P = 0.323). In conclusion, both high and low birth weight in individuals may be among the important risk factors for neuroblastoma development.