Paget's Disease Mimicking Bone Metastasis in a Patient with Neuroendocrine Tumor on Ga-68-DOTANOC PET/CT

GEZER N. S., BALCI A., ÖZDOĞAN Ö., Ozaksoy D.

JOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY, cilt.100, sa.1, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 100 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5334/jbr-btr.903
  • Dergi Adı: JOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Metastasis, Neuroendocrine tumors, Paget's disease, PET/CT, Somatostatin, Ga-68-DOTANOC, SCINTIGRAPHY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Somatostatin (SST) is a neuropeptide present in neurons, endocrine cells, and a wide range of neuroendocrine tumors (NETs). Ga-68-DOTATOC, Ga-68-DOTANOC, and Ga-68-DOTATATE are current SST analogues used for PET/CT which bind to SST receptors expressed in NETs. These SST analogues have been used successfully for diagnosis of SST-expressing tumors with a more sensitive detection technique than conventional scintigraphy. However, there is a lack of clinical data on the differentiation between NETs and other malignant tumors or benign pathological conditions. Here, we report a case of Paget's disease mimicking bone metastasis of NET on PET/CT due to increased Ga-68-DOTANOC uptake and review examples of similar cases in the literature.