α-defensin expression in the gastric tissue of children with helicobacter pylori-associated chronic gastritis: An immunohistochemical study


Soylu O. B., ÖZTÜRK Y., ÖZER E.

Journal of Pediatric Gastroenterology and Nutrition, cilt.46, sa.4, ss.474-477, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/mpg.0b013e31815a9923
  • Dergi Adı: Journal of Pediatric Gastroenterology and Nutrition
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.474-477
  • Anahtar Kelimeler: children, chronic gastritis, defensin, Helicobacter pylori, EPITHELIAL-CELLS, INNATE IMMUNITY, INFECTION, NEWBORN, SYSTEM, HBD-2
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

In this study, we evaluated the expression of α-defensin and its correlation with histological criteria in children with and without Helicobacter pylori-associated gastritis. Forty-five children were included. Immunohistochemical staining was performed and the relationship between α-defensin immunoscoring and H pylori status and histological criteria was evaluated. Expression of α-defensin was significantly higher in the H pylori-positive group (P < 0.001) and it was significantly associated with higher grades of chronic inflammation and neutrophil density (P < 0.001 for both). Our data show that α-defensin expression is increased in H pylori infection in childhood and is associated with inflammatory tissue damage. © 2008 Lippincott Williams & Wilkins, Inc.