Identification of Transcriptional and Metabolic Programs Related to Mammalian Cell Size

Mlettinen T. P., Pessa H. K. J., Caldez M. J., Fuhrer T., DİRİL M. K., Sauer U., ...More

CURRENT BIOLOGY, vol.24, no.6, pp.598-608, 2014 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 24 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1016/j.cub.2014.01.071
  • Journal Name: CURRENT BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.598-608
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Regulation of cell size requires coordination of growth and proliferation. Conditional loss of cyclin-dependent kinase 1 in mice permits hepatocyte growth without cell division, allowing us to study cell size in vivo using transcriptomics and metabolomics.