The Effect of Dichloronitrophenol on Amyloid Beta Toxicity and Steroid Levels

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Örmen M., Gursoy Calan Ö., Ergur U. B., Akan P.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.34, sa.1, ss.16-31, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2017
  • Dergi Adı: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.16-31
  • Anahtar Kelimeler: Dichloronitrophenol, Amyloid Beta Toxicity, SH-SY5Y cells, Neurostreroids, HUMAN NEUROBLASTOMA-CELLS, ALZHEIMERS-DISEASE, DEHYDROEPIANDROSTERONE DHEA, CEREBRAL-ISCHEMIA, OXIDATIVE STRESS, IN-VITRO, BRAIN, PEPTIDE, PREGNENOLONE, METABOLISM
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

In Alzheimer's disease (AD), which is the most common cause of dementia, the accumulation of amyloid beta (AB) peptides has a causal role in the neurodegeneration process. AB peptides can induce synthesis of dehydroepiandrosterone (DHEA), which is a precursor of various steroids. Neurosteroids are modulators of neuronal survival and may have different effects depending on whether they are free or sulfa-conjugated.