The Effect of Dichloronitrophenol on Amyloid Beta Toxicity and Steroid Levels

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Örmen M., Gursoy Calan Ö., Ergur U. B., Akan P.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.34, no.1, pp.16-31, 2017 (SCI-Expanded, Scopus, TRDizin)

  • Publication Type: Article / Article
  • Volume: 34 Issue: 1
  • Publication Date: 2017
  • Journal Name: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.16-31
  • Keywords: Dichloronitrophenol, Amyloid Beta Toxicity, SH-SY5Y cells, Neurostreroids
  • Open Archive Collection: AVESIS Open Access Collection
  • Dokuz Eylül University Affiliated: Yes

Abstract

In Alzheimer's disease (AD), which is the most common cause of dementia, the accumulation of amyloid beta (AB) peptides has a causal role in the neurodegeneration process. AB peptides can induce synthesis of dehydroepiandrosterone (DHEA), which is a precursor of various steroids. Neurosteroids are modulators of neuronal survival and may have different effects depending on whether they are free or sulfa-conjugated.