Relationship between non-steroidal anti-inflammatory drug use and Helicobacter pylori infection in bleeding or uncomplicated peptic ulcers: A case-control study

Okan A., Tankurt E., Aslan B., Akpinar H., Simsek I., Gonen O.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.18, no.1, pp.18-25, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1046/j.1440-1746.2003.02889.x
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.18-25
  • Keywords: gastrointestinal bleeding, Helicobacter pylori, non-steroidal anti-inflammatory drugs, peptic ulcer, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, RAPID UREASE TEST, GASTRIC-ULCER, RISK, ERADICATION, DIAGNOSIS, ASPIRIN, TRIAL, SENSITIVITY, DISEASE
  • Dokuz Eylül University Affiliated: Yes


Background: and Aims: Non-steroidal anti-inflammatory drug (NSAID) use has been closely associated with an increased risk of bleeding peptic ulcers, while the prevalence of Helicobacter pylori infection has been reported to be lower in bleeding ulcers than in non-bleeding ones. However, whether an interaction exists between NSAID use and H. pylori infection has not clearly been elucidated yet. The aims of this study were to determine the frequency of NSAID use and H. pylori infection, to predict risk factors in bleeding peptic ulcers and to determine whether NSAID use and H. pylori infection interact with each other.