GENOTYPING AND ANALYSIS OF rs7501939 POLYMORPHISM FOR PROSTATE CANCER

Ozkan E., ERDEMİR ÜSTÜNDAĞ A., Torer B. D., Tasci A. I., BAŞBINAR Y., ELLİDOKUZ H., ...Daha Fazla

SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI, cilt.6, sa.1, ss.101-107, 2015 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 1
  • Basım Tarihi: 2015
  • Dergi Adı: SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals
  • Sayfa Sayıları: ss.101-107
  • Anahtar Kelimeler: Prostate cancer, single nucleotide polymorphism (SNP), SNP genotyping
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Prostate cancer is the second most common cause of death from cancer among men in Turkey. It is known that genetics plays a critical role in prostate cancer susceptibility. Several genome wide association studies reported that rs7501939 polymorphism was significantly associated with prostate cancer. To confirm association of rs7501939 alleles with prostate cancer in our population, genotyping was conducted by using the iPLEX assay in study group which consists of 85 prostate cancer patients and 90 healty controls. In this study, previous reports of rs7501939 variant association with prostate cancer was not confirmed for our population. The odds ratio for prostate cancer was 0,75 (95% CI=0,48-1,18) for carriers of any T allele compared with noncarriers (p=0,211). Chi square and Fisher's exact test results showed that rs7501939 variant was not statistically associated with clinico-pathological variables of prostate cancer patients in our population.