Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study

Gerss, Joachim; Roth, Johannes; Holzinger, Dirk; Ruperto, Nicolino; Wittkowski, Helmut; Frosch, Michael; Wulffraat, Nico; Wedderburn, Lucy; Stanevicha, Valda; Mihaylova, Dimitrina; Harjacek, Miroslav; Len, Claudio; Toppino, Claudia; Masi, Massimo; Minden, Kirsten; Saurenmann, Traudel; Uziel, Yosef; Vesely, Richard; Teresa Apaz, Maria; Kuester, Rolf-Michael; Rua Elorduy, Maria; Burgos-Vargas, Ruben; Ioseliani, Maka; Magni-Manzoni, Silvia; Unsal, ŞEVKET; Anton, Jordi; Balogh, Zsolt; Hagelberg, Stefan; Mazur-Zielinska, Henryka; Tauber, Tsivia; Martini, Alberto; Foell, Dirk

doi:10.1136/annrheumdis-2012-201329

Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study

Gerss J., Roth J., Holzinger D., Ruperto N., Wittkowski H., Frosch M., ...More

ANNALS OF THE RHEUMATIC DISEASES, vol.71, no.12, pp.1991-1997, 2012 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 71 Issue: 12
Publication Date: 2012
Doi Number: 10.1136/annrheumdis-2012-201329
Journal Name: ANNALS OF THE RHEUMATIC DISEASES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1991-1997
Dokuz Eylül University Affiliated: Yes

Abstract

Objectives Juvenile idiopathic arthritis (JIA) is a chronic inflammatory joint disease affecting children. Even if remission is successfully induced, about half of the patients experience a relapse after stopping anti-inflammatory therapy. The present study investigated whether patients with JIA at risk of relapse can be identified by biomarkers even if clinical signs of disease activity are absent.