Diffusion tensor imaging in first degree relatives of schizophrenia and bipolar disorder patients


Arat H. E., Chouinard V., Cohen B. M., Lewandowski K. E., Oenguer D.

SCHIZOPHRENIA RESEARCH, vol.161, pp.329-339, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 161
  • Publication Date: 2015
  • Doi Number: 10.1016/j.schres.2014.12.008
  • Journal Name: SCHIZOPHRENIA RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.329-339
  • Keywords: Psychosis, White matter, Endophenotype, At risk, DTI, WHITE-MATTER ABNORMALITIES, HIGH GENETIC RISK, ULTRA-HIGH-RISK, RECENT-ONSET SCHIZOPHRENIA, UNAFFECTED RELATIVES, 1ST-DEGREE RELATIVES, NEUROCOGNITIVE ENDOPHENOTYPES, 1ST-EPISODE SCHIZOPHRENIA, FRACTIONAL ANISOTROPY, PSYCHIATRIC-DISORDERS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: White matter (WM) abnormalities are one of the most widely and consistently reported findings in schizophrenia (SZ) and bipolar disorder (BD). If these abnormalities are inherited determinants of illness, suitable to be classified as an endophenotype, relatives of patients must also have them at higher rate compared to the general population. In this review, we evaluate published diffusion tensor imaging (DTI) studies comparing first degree relatives of SZ and BD patients and healthy control subjects.