Diffusion tensor imaging in first degree relatives of schizophrenia and bipolar disorder patients

Arat H. E., Chouinard V., Cohen B. M., Lewandowski K. E., Oenguer D.

SCHIZOPHRENIA RESEARCH, cilt.161, ss.329-339, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 161
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.schres.2014.12.008
  • Dergi Adı: SCHIZOPHRENIA RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.329-339
  • Anahtar Kelimeler: Psychosis, White matter, Endophenotype, At risk, DTI, WHITE-MATTER ABNORMALITIES, HIGH GENETIC RISK, ULTRA-HIGH-RISK, RECENT-ONSET SCHIZOPHRENIA, UNAFFECTED RELATIVES, 1ST-DEGREE RELATIVES, NEUROCOGNITIVE ENDOPHENOTYPES, 1ST-EPISODE SCHIZOPHRENIA, FRACTIONAL ANISOTROPY, PSYCHIATRIC-DISORDERS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objectives: White matter (WM) abnormalities are one of the most widely and consistently reported findings in schizophrenia (SZ) and bipolar disorder (BD). If these abnormalities are inherited determinants of illness, suitable to be classified as an endophenotype, relatives of patients must also have them at higher rate compared to the general population. In this review, we evaluate published diffusion tensor imaging (DTI) studies comparing first degree relatives of SZ and BD patients and healthy control subjects.