Erythropoietin prevents lymphoid apoptosis but has no effect on survival in experimental sepsis
PEDIATRIC RESEARCH, vol.74, no.2, pp.148-153, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 74 Issue: 2
- Publication Date: 2013
- Doi Number: 10.1038/pr.2013.86
- Journal Name: PEDIATRIC RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.148-153
- Dokuz Eylül University Affiliated: Yes
Abstract
BACKGROUND: Lymphoid apoptosis in sepsis is associated with poor outcome, and prevention of apoptosis frequently improves survival in experimental models of sepsis. Recently, erythropoietin (EPO) was shown to protect against lipopolysaccharide (LPS)-induced mortality. As cecal ligation and puncture (CLP) is a clinically more relevant model of sepsis, we evaluated the effect of EPO on CLP-induced lymphoid tissue apoptosis and mortality.