Erythropoietin prevents lymphoid apoptosis but has no effect on survival in experimental sepsis

Koroglu T. F., Yılmaz O., Gokmen N., Tuğyan K., Baskin H., Yüksel Eğrilmez M.

PEDIATRIC RESEARCH, vol.74, no.2, pp.148-153, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1038/pr.2013.86
  • Journal Name: PEDIATRIC RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.148-153
  • Dokuz Eylül University Affiliated: Yes

Abstract

BACKGROUND: Lymphoid apoptosis in sepsis is associated with poor outcome, and prevention of apoptosis frequently improves survival in experimental models of sepsis. Recently, erythropoietin (EPO) was shown to protect against lipopolysaccharide (LPS)-induced mortality. As cecal ligation and puncture (CLP) is a clinically more relevant model of sepsis, we evaluated the effect of EPO on CLP-induced lymphoid tissue apoptosis and mortality.