Erythropoietin prevents lymphoid apoptosis but has no effect on survival in experimental sepsis

Koroglu, Tolga; Yılmaz, OSMAN; Gokmen, ALİ; Tuğyan, KAZIM; Baskin, Huseyin; Yüksel Eğrilmez, MEHTAP

doi:10.1038/pr.2013.86

Erythropoietin prevents lymphoid apoptosis but has no effect on survival in experimental sepsis

Koroglu T. F., Yılmaz O., Gokmen N., Tuğyan K., Baskin H., Yüksel Eğrilmez M.

PEDIATRIC RESEARCH, cilt.74, sa.2, ss.148-153, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 74 Sayı: 2
Basım Tarihi: 2013
Doi Numarası: 10.1038/pr.2013.86
Dergi Adı: PEDIATRIC RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.148-153
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

BACKGROUND: Lymphoid apoptosis in sepsis is associated with poor outcome, and prevention of apoptosis frequently improves survival in experimental models of sepsis. Recently, erythropoietin (EPO) was shown to protect against lipopolysaccharide (LPS)-induced mortality. As cecal ligation and puncture (CLP) is a clinically more relevant model of sepsis, we evaluated the effect of EPO on CLP-induced lymphoid tissue apoptosis and mortality.