Erythropoietin prevents lymphoid apoptosis but has no effect on survival in experimental sepsis

Koroglu T. F., Yılmaz O., Gokmen N., Tuğyan K., Baskin H., Yüksel Eğrilmez M.

PEDIATRIC RESEARCH, cilt.74, sa.2, ss.148-153, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1038/pr.2013.86
  • Dergi Adı: PEDIATRIC RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.148-153
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

BACKGROUND: Lymphoid apoptosis in sepsis is associated with poor outcome, and prevention of apoptosis frequently improves survival in experimental models of sepsis. Recently, erythropoietin (EPO) was shown to protect against lipopolysaccharide (LPS)-induced mortality. As cecal ligation and puncture (CLP) is a clinically more relevant model of sepsis, we evaluated the effect of EPO on CLP-induced lymphoid tissue apoptosis and mortality.