Akademik Veri Yönetim Sistemi
SOPATE 2023, Brussels, Belçika, 7 - 08 Aralık 2023, ss.2, (Özet Bildiri)
The Effect of Microbiota and Related Blood Tryptophan Metabolites on Pain in Patients Undergoing Lumbar Disc Herniation Surgery Yunus Celik1, Hale Aksu Erdost1 Anesthesiology and Reanimation, Dokuz Eylul University Hospital, Turkey Introduction: The gut microbiota plays a critical role in many pain conditions. In light of these mechanisms and pathways, we investigated the relationship between tryptophan metabolites and acute pain including the correlation between VAS scores and tryptophan metabolites. Materials and Methods: Adult patients who would undergo LDH surgery under general anesthesia were included in our study. Blood samples were taken from the patients before surgery, at the 8th and 24th hours after surgery, and VAS scores were recorded simultaneously. The correlation between tryptophan metabolites and VAS scores was evaluated. At the same time, demographic data, vital signs, surgery time, anesthetic drugs and VAS correlation were evaluated. Results: A significant difference was found between the preoperative VAS score of our patients and the 24-hour postoperative VAS score. Tryptophan and its metabolites in blood samples; It was determined that there were statistically significant changes in picolinic acid, kynurenic acid, xanthinuric acid data. Moderate positive correlation was found between 24-hour postoperative VAS and 24-hour postoperative quinolinic acid. There was a moderate positive correlation between preoperative picolinic acid and 8-hour postoperative picolinic acid with age. The change between preoperative 3-OH kynurenine and 8-hour postoperative 3-OH kynurenine was moderately negative and poorly correlated with operative time. Conclusion: Our findings support a relationship between microbiota and acute pain and suggest that tryptophan metabolites detected in blood may be a biomarker for pain treatment. Large sample size and more comprehensive clinical studies are needed to better understand the relationship between acute pain and microbiota metabolites. Keywords: Tryptophan, Picolinic acid, Kynurenic acid, Xanthinuric acid, Quinolinic acid, Microbiota, Acute Pain