Nitric oxide as an activity marker in multiple sclerosis

Acar G., Idiman F., Idiman E., Kirkali G., Cakmakci H., Ozakbas S.

JOURNAL OF NEUROLOGY, cilt.250, sa.5, ss.588-592, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 250 Sayı: 5
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1007/s00415-003-1041-0
  • Dergi Adı: JOURNAL OF NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.588-592
  • Anahtar Kelimeler: multiple sclerosis, activity marker, nitric oxide
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Nitric oxide (NO) molecules have one of the most important roles in the pathogenesis of multiple sclerosis (MS). It has been stated that a continuous and high concentration of NO metabolites in CSF and in the serum of MS patients in relapse may cause toxic damage to myelin and oligodendroglia. The aim of this study was to investigate whether NO is a marker of disease activity and is correlated with other disease activity markers such as active lesions on brain magnetic resonance imaging (MRI) and increased immunoglobulin G (IgG) index.