Biochemical biomarkers for detection of nephrotoxicity and cardiotoxicity in cisplatin administered rats


Colak A., ALTUN Z. S., DİNİZ ÜNLÜ A. G., YILMAZ O., AKTAŞ S.

IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI, vol.3, no.2, pp.105-109, 2013 (ESCI) identifier

Abstract

Objective: Cisplatin is a widely used anticancer drug. The aim of this study is to investigate biochemical biomarkers that can be used for identification of cisplatin cardiotoxicity and nephrotoxicity. Methods: This study was conducted on female Wistar Albino rats weighing 200-300 g. Rats were seperated into two groups as cisplatin administered group (n=5) and the control group (n=6). Intraperitoneal cisplatin (cumulative dose 16 mg/kg) was administered to the first group and the second group received physiological serum. All rats were sacrificed on day 14 of the study. BNP, troponin I, CK MB, urea, creatinine levels were measured in rat blood samples. All blood samples were stored at -80 degrees C until measurement. Results: Troponin I, urea and creatinine concentrations of cisplatin administered rats were signicantly higher from those of the control rats. Conclusion: Urea and creatinine values may be used for identification of cisplatin nephrotoxicity and troponin I may be a good biomarker for detection of cisplatin cardiotoxicity.