Activated protein C reduces intestinal injury in an experimental model of necrotizing enterocolitis

KUMRAL A., Yesilirmak D. C., TUĞYAN K., BASKIN A. H., Tekman I., DUMAN N., ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.45, sa.3, ss.483-489, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jpedsurg.2009.07.077
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.483-489
  • Anahtar Kelimeler: Necrotizing enterocolitis, Newborn, Activated protein C, NECROSIS-FACTOR-ALPHA, NITRIC-OXIDE, INFLAMMATION, RATS, PATHOGENESIS, COAGULATION, INHIBITION, THROMBOSIS, ISCHEMIA, THERAPY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Necrotizing enterocolitis is a devastating intestinal disease of premature infants. Although activated protein C (APC) is well defined as a physiologic anticoagulant, emerging data suggest that it also has cytoprotective, antiinflammatory, and antiapoptotic properties. There is no study on active protein C administration for necrotizing enterocolitis in animal models.