Activated protein C reduces intestinal injury in an experimental model of necrotizing enterocolitis


KUMRAL A., Yesilirmak D. C., TUĞYAN K., BASKIN A. H., Tekman I., DUMAN N., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.45, no.3, pp.483-489, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1016/j.jpedsurg.2009.07.077
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.483-489
  • Keywords: Necrotizing enterocolitis, Newborn, Activated protein C, NECROSIS-FACTOR-ALPHA, NITRIC-OXIDE, INFLAMMATION, RATS, PATHOGENESIS, COAGULATION, INHIBITION, THROMBOSIS, ISCHEMIA, THERAPY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Necrotizing enterocolitis is a devastating intestinal disease of premature infants. Although activated protein C (APC) is well defined as a physiologic anticoagulant, emerging data suggest that it also has cytoprotective, antiinflammatory, and antiapoptotic properties. There is no study on active protein C administration for necrotizing enterocolitis in animal models.