Comparison of the Effects of 13-cis Retinoic Acid and Melatonin on the Viabilities of SH-SY5Y Neuroblastoma Cell Line

Tosun M., Soysal Y., Gocmen Mas N. N., Karabekir H. S.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, cilt.57, sa.3, ss.147-151, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3340/jkns.2015.57.3.147
  • Dergi Adı: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.147-151
  • Anahtar Kelimeler: Neuroblastoma, Melatonin, 13-cis retinoic acid, Cancer, Cell viability, Isotretinoin, OXIDATIVE STRESS, CULTURED-CELLS, INDUCED NEUROTOXICITY, INDUCED APOPTOSIS, ALPHA-SYNUCLEIN, OKADAIC ACID, NITRIC-OXIDE, PROTECTS, DEATH, BAX
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective : Neuroblastoma is one of common childhood tumors. Although its mortality is very high, there is no effective treatment yet. The aim of this project is to evaluate cytotoxic effects of melatonin (MLT) an endogen hormone and 13-cis retinoic acid (13-cis-RA) also named as isotretinoin an analogue of vitamin A on neuroblastoma SH-SY5Y cell line.