Exercise increases leptin levels correlated with IGF-1 in hippocampus and prefrontal cortex of adolescent male and female rats

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Uysal Harzadın N., Agilkaya S., Sisman A., Camsari U. M., Gençoğlu C., Dayı A., ...More

JOURNAL OF CHEMICAL NEUROANATOMY, vol.81, pp.27-33, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81
  • Publication Date: 2017
  • Doi Number: 10.1016/j.jchemneu.2017.02.004
  • Journal Name: JOURNAL OF CHEMICAL NEUROANATOMY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.27-33
  • Keywords: Exercise, Hippocampus, Prefrontal cortex, Leptin, Leptin receptor, IGF1, Rat, GROWTH-FACTOR-I, LONG-TERM POTENTIATION, AEROBIC EXERCISE, GENE-EXPRESSION, DENTATE GYRUS, SERUM LEPTIN, BRAIN, RECEPTOR, MEMORY, ANXIETY
  • Dokuz Eylül University Affiliated: Yes

Abstract

It is known that regular aerobic exercise has positive effects on hippocampus and prefrontal cortex. We have previously have been able to demonstrate that aerobic exercise increased IGF-1 in hippocampus. Leptin, which is associated with cognitive functions, is also involved in fat metabolism and stimulates energy consumption. While it is known that leptin stimulates IGF-1 production in hepatocytes, little known is on the link between IGF-1 and leptin in brain during aerobic exercise.