Exercise increases leptin levels correlated with IGF-1 in hippocampus and prefrontal cortex of adolescent male and female rats

Uysal Harzadın, NAZAN; Agilkaya, Sinem; Sisman, ALİRIZA; Camsari, Ulas; Gençoğlu, CELAL; Dayı, AYFER; Aksu, İLKAY; Baykara, BAŞAK; Cingöz, SULTAN; Kiray, MÜGE

doi:10.1016/j.jchemneu.2017.02.004

Exercise increases leptin levels correlated with IGF-1 in hippocampus and prefrontal cortex of adolescent male and female rats

Uysal Harzadın N., Agilkaya S., Sisman A., Camsari U. M., Gençoğlu C., Dayı A., ...More

JOURNAL OF CHEMICAL NEUROANATOMY, vol.81, pp.27-33, 2017 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 81
Publication Date: 2017
Doi Number: 10.1016/j.jchemneu.2017.02.004
Journal Name: JOURNAL OF CHEMICAL NEUROANATOMY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.27-33
Keywords: Exercise, Hippocampus, Prefrontal cortex, Leptin, Leptin receptor, IGF1, Rat
Open Archive Collection: AVESIS Open Access Collection
Dokuz Eylül University Affiliated: Yes

Abstract

It is known that regular aerobic exercise has positive effects on hippocampus and prefrontal cortex. We have previously have been able to demonstrate that aerobic exercise increased IGF-1 in hippocampus. Leptin, which is associated with cognitive functions, is also involved in fat metabolism and stimulates energy consumption. While it is known that leptin stimulates IGF-1 production in hepatocytes, little known is on the link between IGF-1 and leptin in brain during aerobic exercise.