Exercise increases leptin levels correlated with IGF-1 in hippocampus and prefrontal cortex of adolescent male and female rats

Uysal Harzadın, NAZAN; Agilkaya, Sinem; Sisman, ALİRIZA; Camsari, Ulas; Gençoğlu, CELAL; Dayı, AYFER; Aksu, İLKAY; Baykara, BAŞAK; Cingöz, SULTAN; Kiray, MÜGE

doi:10.1016/j.jchemneu.2017.02.004

Exercise increases leptin levels correlated with IGF-1 in hippocampus and prefrontal cortex of adolescent male and female rats

Uysal Harzadın N., Agilkaya S., Sisman A., Camsari U. M., Gençoğlu C., Dayı A., ...Daha Fazla

JOURNAL OF CHEMICAL NEUROANATOMY, cilt.81, ss.27-33, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 81
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.jchemneu.2017.02.004
Dergi Adı: JOURNAL OF CHEMICAL NEUROANATOMY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.27-33
Anahtar Kelimeler: Exercise, Hippocampus, Prefrontal cortex, Leptin, Leptin receptor, IGF1, Rat
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

It is known that regular aerobic exercise has positive effects on hippocampus and prefrontal cortex. We have previously have been able to demonstrate that aerobic exercise increased IGF-1 in hippocampus. Leptin, which is associated with cognitive functions, is also involved in fat metabolism and stimulates energy consumption. While it is known that leptin stimulates IGF-1 production in hepatocytes, little known is on the link between IGF-1 and leptin in brain during aerobic exercise.