Akademik Veri Yönetim Sistemi
Modern Surface Engineering Treatments, Mahmood Aliofkhazraei, Editör, IntechOpen Publishing, Rijeka, ss.185-208, 2013
In the last two decades a lot of attention has been payed on the preparation of nanoscaled
materials and recently, depending on the development of new fabrication and characterization
techniques, materials composed of a few atoms up to hundreds of atoms can be synthesized
and their properties determined easily. Nano sized materials, as compared to their bulk
counterparts, exhibit new characteristic optical, electrical and magnetic properties due to the
enhanced surface to volume ratio and quantum confinement effects emerging in these size
ranges. These new features of nanoparticles offers them the possibility to be used in a wide
range of technological (magnetic data storage, refrigeration), environmental (catalysts,
hydrogen storage), energy (lithium-ion batteries, solar cells) and biomedical applications. In
biomedical applications there are different kind of nanoparticles used like metallic,
magnetic, fluorescent (quantum dot), polymeric and protein-based nanoparticles, in which much of the research in this field is focused on the magnetic nanoparticles. In this
review only magnetic nanoparticles, which are composed of a magnetic core surrounded by
a functionalized biocompatible surface shell will be concerned, where several reviews on other
type of nanoparticles are available in the literature. In the scope of the text particular attention
will be payed on superparamagnetic iron oxide (SPIONs), which is beyond the most studied
one among all types of magnetic nanoparticles. In the beginning of the article, the biomedical
applications of magnetic nanoparticles are summarized together with the key factors effecting
the nanoparticles’ performance in these applications. Then the requirement for the surface
treatment of the nanoparticles are discussed in the context of colloidal stability, toxicity
(biocompatibility) and functionalization. Finally, the followed procedures for the surface
coating of magnetic nanoparticles are briefly explained and the different materials used as
surface coatings are listed in detail with examples from literature.