Recognition of glycosaminoglycan chemical patterns using an unbiased sensor array
CHEMICAL SCIENCE, vol.4, no.5, pp.2076-2080, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 4 Issue: 5
- Publication Date: 2013
- Doi Number: 10.1039/c3sc22279a
- Journal Name: CHEMICAL SCIENCE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.2076-2080
- Dokuz Eylül University Affiliated: No
Abstract
A sensor array composed of eight functionalized gold nanoparticles and a fluorescent polymer was utilized to identify 11 glycosaminoglycans (GAGs) by their chemical signatures. Particle ligand structure was key in differentiating analytes, with aromatic and specific sugar functionalities recognizing GAG structural parameters including sulfonation, acetylation, epimeric structure, size, and charge.