Recognition of glycosaminoglycan chemical patterns using an unbiased sensor array

ELÇİ Ş. G., Moyano D. F., Rana S., Tong G. Y., Phillips R. L., Bunz U. H. F., ...Daha Fazla

CHEMICAL SCIENCE, cilt.4, sa.5, ss.2076-2080, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1039/c3sc22279a
  • Dergi Adı: CHEMICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2076-2080
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

A sensor array composed of eight functionalized gold nanoparticles and a fluorescent polymer was utilized to identify 11 glycosaminoglycans (GAGs) by their chemical signatures. Particle ligand structure was key in differentiating analytes, with aromatic and specific sugar functionalities recognizing GAG structural parameters including sulfonation, acetylation, epimeric structure, size, and charge.