Malignant pleural mesothelioma in a child: long-term survival with ICE-WAC chemotherapy regimen

Mutafoglu-Uysal K., Kargi A., Sarialioglu F., Olgun N., Kovanlikaya A.

TURKISH JOURNAL OF PEDIATRICS, cilt.44, sa.3, ss.244-247, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 3
  • Basım Tarihi: 2002
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.244-247
  • Anahtar Kelimeler: malignant mesothelioma, ICE, ICE-VAC, chemotherapy, rare tumors, PERITONEAL MESOTHELIOMA
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Malignant mesothelioma is a very rare tumor in childhood. Presently, treatment of this disease continues to be frustrating and prognosis remains poor. We here report a pediatric case of malignant pleural mesothelioma. who gave a complete response to ICE-VAC chemotherapy regimen and achieved a longterm survival. An eight-year-old girl underwent exploratory thoracotomy and decortication because of a unilateral loculated and multicystic pleural effusion. Histopathological diagnosis was sarcomatoid pleural malignant mesothelioma. After decortication, chemotherapy with ICE (ifosfamide, carboplatin, etoposide) - VAC (vincristine, adriamycin, cyclophosphamide) combination was started. Six courses of chemotherapy resulted in complete clinical and radiological tumor response. She did not receive any further therapy and remains disease-free three years after the first remission. ICE-VAC chemotherapy combination resulted in a complete tumor response and a long-term disease-free survival for the presented case. The efficacy of this chemotherapy regimen in malignant mesothelioma needs to be documented in future trials.