Prevention of Pazopanib-Induced Prolonged Cardiac Repolarization and Proarrhythmic Effects

Akman T., Erbas O., AKMAN L., Yilmaz A. U.

ARQUIVOS BRASILEIROS DE CARDIOLOGIA, cilt.103, sa.5, ss.403-409, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 103 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5935/abc.20140138
  • Dergi Adı: ARQUIVOS BRASILEIROS DE CARDIOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.403-409
  • Anahtar Kelimeler: Arrhythmias, Cardiac / therapy, Pyrimidines / adverse effects, Heart Conduction System / physiology, Heart / physiology, QT-INTERVAL PROLONGATION, REGULATORY IMPLICATIONS, ANTIARRHYTHMIC DRUGS, POLICY CONFERENCE, EUROPEAN-SOCIETY, MANAGEMENT, POTASSIUM, RISK, ONCOLOGISTS, SAFETY
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Background: Pazopanib (PZP) may induce prolonged cardiac repolarization and proarrhythmic effects, similarly to other tyrosine kinase inhibitors. Objectives: To demonstrate PZP-induced prolonged cardiac repolarization and proarrhythmic electrophysiological effects and to investigate possible preventive effects of metoprolol and diltiazem on ECG changes (prolonged QT) in an experimental rat model.