Prevention of Pazopanib-Induced Prolonged Cardiac Repolarization and Proarrhythmic Effects


Akman T., Erbas O., AKMAN L., Yilmaz A. U.

ARQUIVOS BRASILEIROS DE CARDIOLOGIA, vol.103, no.5, pp.403-409, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.5935/abc.20140138
  • Journal Name: ARQUIVOS BRASILEIROS DE CARDIOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.403-409
  • Keywords: Arrhythmias, Cardiac / therapy, Pyrimidines / adverse effects, Heart Conduction System / physiology, Heart / physiology, QT-INTERVAL PROLONGATION, REGULATORY IMPLICATIONS, ANTIARRHYTHMIC DRUGS, POLICY CONFERENCE, EUROPEAN-SOCIETY, MANAGEMENT, POTASSIUM, RISK, ONCOLOGISTS, SAFETY
  • Dokuz Eylül University Affiliated: No

Abstract

Background: Pazopanib (PZP) may induce prolonged cardiac repolarization and proarrhythmic effects, similarly to other tyrosine kinase inhibitors. Objectives: To demonstrate PZP-induced prolonged cardiac repolarization and proarrhythmic electrophysiological effects and to investigate possible preventive effects of metoprolol and diltiazem on ECG changes (prolonged QT) in an experimental rat model.