The Relationship Between Lithium and Cancer Proliferation: A Case-Based Review of the Literature.

Ozerdem A., Ceylan D., Targitay B.

Current drug metabolism, vol.19, no.8, pp.653-662, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 8
  • Publication Date: 2018
  • Doi Number: 10.2174/1389200219666180430095933
  • Journal Name: Current drug metabolism
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.653-662
  • Keywords: Lithium, cancer proliferation, urinary tract cancer, tumor, GSK-3, redox modulations, mitochondrial damage, GLYCOGEN-SYNTHASE KINASE-3, RENAL-CELL CARCINOMA, OXIDATIVE STRESS MARKERS, INDUCED DNA-DAMAGE, FACTOR-KAPPA-B, BIPOLAR DISORDER, VALPROIC ACID, HISTONE DEACETYLASE, IN-VITRO, MITOCHONDRIAL DYSFUNCTION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: The incidence and mortality rates of cancer in patients with Bipolar Disorder (BD) is higher compared with the general population. The role of Lithium (Li) in cancer proliferation/inhibition is still a controversial issue in the literature.