Evaluation of the neuroprotective effects of ozone in an experimental spine injury model

Gurkan G., Sayin M., KIZMAZOĞLU C., ERDOĞAN M. A., YİĞİTTÜRK G., Yilmaz H. E., ...More

JOURNAL OF NEUROSURGERY-SPINE, vol.33, no.3, pp.406-414, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.3171/2020.2.spine191439
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.406-414
  • Keywords: ozone treatment, methylprednisolone, experimental spinal cord injury, IL-6, TAS, total oxidant status, CORD ISCHEMIA/REPERFUSION INJURY, HYPERBARIC-OXYGEN TREATMENT, THERAPY, METHYLPREDNISOLONE, RESTORATION, HYPOTHERMIA, ISCHEMIA, SURGERY, TRAUMA, ACID
  • Dokuz Eylül University Affiliated: Yes


OBJECTIVE The pathophysiology of spine injury consists of primary and secondary damage mechanisms. The vast majority of treatments aim to prevent or at least stop the progression of secondary neurotoxic events during the acute period. Ozone has been found to have potent antiinflammatory effects, to activate the immune system, and to have a substantial impact on the antioxidant system. In this study the authors aimed to evaluate the neuroprotective effects of ozone and their possible roles in recovery from spine injury, assessed based on biochemical, histological, and neurological parameters using an experimental spine injury model in rats.