Alzheimer's Disease Patients Generate Late and Reduced Cortical Activity For Movement Preparation

Yener G., Yilmaz M., Oguz M., Kurt P.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.27, no.2, pp.150-159, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2010
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.150-159
  • Keywords: Alzheimer's Disease, movement related cortical potentials, Bereitshaftspotential, executive functions, SUPPLEMENTARY MOTOR AREA, BRAIN FUNCTIONAL CONNECTIVITY, MILD COGNITIVE IMPAIRMENT, THETA-OSCILLATIONS, EEG, POTENTIALS, DEMENTIA, CORTEX, PREMOTOR
  • Dokuz Eylül University Affiliated: Yes


Background: Alzheimer's disease (AD) is a common neurodegenerative disease that affects cognitive functions in the absence of motor signs. However, motor associated functional cortical changes mirror the changes of cognitive network in AD patients. The movement related cortical potentials (MRCP) can be used to investigate the cognitive processes prior to voluntary movement. The neuropsychological deficits that implicate disruption of involving frontal motor network in early AD would also cause alterations in all phases of MRCP. The present study aimed to investigate whether such changes occur in MRCPs of AD patients.