Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report

Tuhan H., ABACI A., SARSIK KUMBARACI B., Ozturk T., OLGUNER M., Catli G., ...Daha Fazla

ACTA CLINICA BELGICA, cilt.72, sa.4, ss.254-258, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/17843286.2016.1215869
  • Dergi Adı: ACTA CLINICA BELGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.254-258
  • Anahtar Kelimeler: Sertoli cell tumor, Testicular microlithiasis, Prepubertal gynecomastia, HORMONE-BINDING GLOBULIN, PEUTZ-JEGHERS-SYNDROME
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Intratubular large cell hyalinizing Sertoli cell neoplasia (ITLCHSCN) resulting from Sertoli cells of the testis are mainly reported in young adults and these are rarely seen in childhood. The most common presenting symptoms of the patients diagnosed with ITLCHSCN are gynecomastia, enlargement in the testicles, increase in growth velocity, and advanced bone age. Symptoms are basically resulting from increased aromatase enzyme activity in Sertoli cells. In this case report, an eight-and-a-half-year-old case presenting with complaint of bilateral gynecomastia since two years, showing no endocrine abnormality in laboratory during two years of follow-up, determined to have progression in bilateral gynecomastia, increase in testicular volumes, advanced bone age, increase in growth velocity in the clinical follow-up, and diagnosed with ITLCHSCN after testis biopsy was presented.