The effects of single dose of methamphetamine on lipid peroxidation levels in the rat striatum and prefrontal cortex

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Acikgoz O., Gonenc S., Kayatekin B. M., Pekctin Ç., Uysal Harzadın N., Dayı A., ...More

EUROPEAN NEUROPSYCHOPHARMACOLOGY, vol.10, no.5, pp.415-418, 2000 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 5
  • Publication Date: 2000
  • Doi Number: 10.1016/s0924-977x(00)00103-6
  • Journal Name: EUROPEAN NEUROPSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.415-418
  • Keywords: dopamine, methamphetamine, oxidative stress, lipid peroxidation, striatum, prefrontal cortex, DISMUTASE TRANSGENIC MICE, SUPEROXIDE-DISMUTASE, OXIDATIVE STRESS, GLUTATHIONE-PEROXIDASE, INDUCED NEUROTOXICITY, DOPAMINE, GLUTAMATE, RELEASE, CATECHOLAMINES, SYNAPTOSOMES
  • Dokuz Eylül University Affiliated: Yes

Abstract

The administration of methamphetamine to experimental animals results in damage to dopaminergic neurons. In the present study, we demonstrated that a single dose (15 mg/kg) of methamphetamine results in production of oxidative stress as demonstrated by increased thiobarbituric acid reactive substances levels in the rat striatum and prefrontal cortex. In conclusion, the results of present study provide further evidence in support of the notion that oxidative stress may play an important role in the methamphetamine-induced neurotoxicity. (C) 2000 Elsevier Science BN. All rights reserved.