Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness


Erbayraktar Z., Alural B., ERBAYRAKTAR R. S., Erkan E. P.

CANCER CELL INTERNATIONAL, vol.16, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 2016
  • Doi Number: 10.1186/s12935-016-0364-8
  • Journal Name: CANCER CELL INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Glioblastoma, Cell division cycle 7, CDC7 inhibitor, Cathepsin S, Kinase inhibitor, CATHEPSIN-S EXPRESSION, DNA-REPLICATION, CANCER, OVEREXPRESSION, KINASE, PROLIFERATION, MICRORNA-451, TEMOZOLOMIDE, CONTRIBUTES, RESISTANCE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Genomic instability is a hallmark of cancer cells, and this cellular phenomenon can emerge as a result of replicative stress. It is possible to take advantage of replicative stress, and enhance it in a targeted way to fight cancer cells. One of such strategies involves targeting the cell division cycle 7-related protein kinase (CDC7), a protein with key roles in regulation of initiation of DNA replication. CDC7 overexpression is present in different cancers, and small molecule inhibitors of the CDC7 have well-documented anti-tumor effects. Here, we aimed to test the potential of CDC7 inhibition as a new strategy for glioblastoma treatment.