Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness

Erbayraktar Z., Alural B., ERBAYRAKTAR R. S., Erkan E. P.

CANCER CELL INTERNATIONAL, cilt.16, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1186/s12935-016-0364-8
  • Dergi Adı: CANCER CELL INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Glioblastoma, Cell division cycle 7, CDC7 inhibitor, Cathepsin S, Kinase inhibitor, CATHEPSIN-S EXPRESSION, DNA-REPLICATION, CANCER, OVEREXPRESSION, KINASE, PROLIFERATION, MICRORNA-451, TEMOZOLOMIDE, CONTRIBUTES, RESISTANCE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Genomic instability is a hallmark of cancer cells, and this cellular phenomenon can emerge as a result of replicative stress. It is possible to take advantage of replicative stress, and enhance it in a targeted way to fight cancer cells. One of such strategies involves targeting the cell division cycle 7-related protein kinase (CDC7), a protein with key roles in regulation of initiation of DNA replication. CDC7 overexpression is present in different cancers, and small molecule inhibitors of the CDC7 have well-documented anti-tumor effects. Here, we aimed to test the potential of CDC7 inhibition as a new strategy for glioblastoma treatment.