A Comparison of Intravenous Levetiracetam and Valproate for the Treatment of Refractory Status Epilepticus in Children

Isguder R., Guzel O., Ceylan G., Yilmaz U., Agin H.

JOURNAL OF CHILD NEUROLOGY, vol.31, no.9, pp.1120-1126, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 9
  • Publication Date: 2016
  • Doi Number: 10.1177/0883073816641187
  • Journal Name: JOURNAL OF CHILD NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1120-1126
  • Keywords: levetiracetam, valproate, refractory status epilepticus, pediatric intensive care unit, CONVULSIVE STATUS EPILEPTICUS, PEDIATRIC STATUS EPILEPTICUS, ACUTE REPETITIVE SEIZURES, UNCONTROLLED STATUS EPILEPTICUS, INTENSIVE-CARE TREATMENT, ANTIEPILEPTIC DRUGS, ILAE COMMISSION, MANAGEMENT, EPILEPSY, CHILDHOOD
  • Dokuz Eylül University Affiliated: No

Abstract

Because of the lack of studies comparing the efficacy and safety of levetiracetam and valproate before the induction of general anesthesia in the treatment of convulsive refractory status epilepticus in children, we aimed to compare the effectiveness of these antiepileptic drugs in patients with convulsive status epilepticus admitted to the Pediatric Intensive Care Unit between 2011 and 2014. Forty-six (59%) of the 78 patients received levetiracetam, and 32 (41%) received valproate for the treatment of refractory status epilepticus. The response rate was not significantly different between the 2 groups. Although no adverse event was noted in patients who received levetiracetam, 4 (12.5%) patients in the valproate group experienced liver dysfunction (P = .025). According to our results, levetiracetam and valproate may be used in the treatment of refractory status epilepticus before the induction of general anesthesia. Levetiracetam appears as effective as valproate, and also safer.