Akademik Veri Yönetim Sistemi
Anestezi Dergisi, cilt.24, sa.2, ss.67-72, 2016 (Scopus)
Introduction: We investigated the role of gender on the effect of neostigmine-antagonised nondepolarizing neuromuscular block. Method: One hundred adult patients were enrolled in this study. The patients were divided into two groups as female group (n=50) and male group (n=50). Anesthesia induction was performed with propofol and fentanyl and maintained with desflurane inhalation to serve as a baseline, control TOF value (TOFc) was recorded and rocuronium 0.5 mg kg-1 was injected thereafter. The duration of TOF value to reach zero (TOF-0) was recorded. Rocuronium injection was repeated in 114 of the initial dose when the TOF ratio recovered to 25% (TOF-25). Total rocuronium dose (TRmg), time interval between rocuronium administrations (TRt) and number of the total rocuronium administrations (TRs) were recorded. At the end of the operation, neostigmine and atropine were administered when TOF ratio reached to 25%, and the duration of the TOF ratio for rising from 25% to 90% (TOF25-90) was recorded. Protruding the tongue (TP) and to lift the head (HL) were also recorded after extubation. Results: There were no differences between the demographic data and surgical duration of the groups. TOF-0 of the male group was longer than that of the female group (219.34 sec vs. 138.84 sec). In the male group TRt was shorter and TRs was higher (p<0.001). TOF25-90 of the male group was also found to be shorter than in the female group (p>0.05). Protruding the tongue and to lift the head were significantly lower in male patients. Conclusion: Gender effects the antagonization speed of nondepolarizing neuromuscular block with neostigmine and nondepolarizing neuromuscular block recovers earlier in men than in woman.