Induction of fetal diuresis with intraamniotic furosemide increases the clearance of intraamniotic substances: An alternative therapy aimed at reducing intraamniotic meconium concentration

HAKGÜDER F. G., Ates O., OLGUNER M., Api A., Ozdogan Ö., Degirmenci B., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.37, no.9, pp.1337-1342, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 9
  • Publication Date: 2002
  • Doi Number: 10.1053/jpsu.2002.35004
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1337-1342
  • Keywords: gastroschisis, amniotic fluid, intestinal damage, intraamniotic furosemide, ALLANTOIC FLUID EXCHANGE, HUMAN NEONATAL URINE, AMNIOTIC-FLUID, INTESTINAL DAMAGE, EXPERIMENTAL GASTROSCHISIS, TRANSABDOMINAL AMNIOINFUSION, SEVERE OLIGOHYDRAMNIOS, PREVENTION, BOWEL, ETIOLOGY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background/Purpose: Contact with amniotic fluid (AF) causes intestinal damage in gastroschisis. Intraamniotic meconium has been shown to be responsible for intestinal damage, and occurrence of this damage has been shown to depend on the concentration of intraamniotic meconium. When intraamniotic meconium concentration is lowered below threshold level by exchanging AF with saline in gastroschisis, intestinal damage can be prevented. Theoretically, induction of fetal diuresis with intraamniotic furosemide may increase AF volume and fetal swallowing rate, thus, increase absorption of AF by intestines; therefore, the clearance of meconium from the AF may increase. An experimental study was planned to investigate the effects of intraamniotic diuretic injection on the clearance of intraamniotic substances.