Induction of fetal diuresis with intraamniotic furosemide increases the clearance of intraamniotic substances: An alternative therapy aimed at reducing intraamniotic meconium concentration

HAKGÜDER F. G., Ates O., OLGUNER M., Api A., Ozdogan Ö., Degirmenci B., ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.37, sa.9, ss.1337-1342, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 9
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1053/jpsu.2002.35004
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1337-1342
  • Anahtar Kelimeler: gastroschisis, amniotic fluid, intestinal damage, intraamniotic furosemide, ALLANTOIC FLUID EXCHANGE, HUMAN NEONATAL URINE, AMNIOTIC-FLUID, INTESTINAL DAMAGE, EXPERIMENTAL GASTROSCHISIS, TRANSABDOMINAL AMNIOINFUSION, SEVERE OLIGOHYDRAMNIOS, PREVENTION, BOWEL, ETIOLOGY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/Purpose: Contact with amniotic fluid (AF) causes intestinal damage in gastroschisis. Intraamniotic meconium has been shown to be responsible for intestinal damage, and occurrence of this damage has been shown to depend on the concentration of intraamniotic meconium. When intraamniotic meconium concentration is lowered below threshold level by exchanging AF with saline in gastroschisis, intestinal damage can be prevented. Theoretically, induction of fetal diuresis with intraamniotic furosemide may increase AF volume and fetal swallowing rate, thus, increase absorption of AF by intestines; therefore, the clearance of meconium from the AF may increase. An experimental study was planned to investigate the effects of intraamniotic diuretic injection on the clearance of intraamniotic substances.