Turk Anesteziyoloji ve Reanimasyon, cilt.26, sa.1, ss.30-33, 1998 (Scopus)
We investigated the sedative and possible analgesic effects of clonidine and compared with midazolam after rectal administration in pediatric patients. Fourty children (ASA grade I, 2-10 years old) undergoing inguinal hernia were designed randomly to receive either clonidine 2.5 μg/kg (n=20) or midazolam 0.5 mg/kg (n=20) 30 minutes before the induction of anaesthesia . Children's level of sedation and degree of acceptance of mask application during induction of anaesthesia were assessed by an anaesthetist unaware of the used drug, whereas postoperative level of pain was assessed by the parent using the Rating Scale. Rectal administration of 2.5 μ/kg clonidine in children didn't produce efficacious and analgesia when compared with 0.5 mg/kg midazolam.