Successful pregnancy in a woman with hypogonadotrophic hypogonadism using low dose hCG after priming with recombinant FSH in an IVF cycle

GÜLEKLİ B., Doǧan E., Aydiner F., Ok E., KARAGÖZ AKIN F.

Journal of the Turkish German Gynecology Association, cilt.8, sa.4, ss.428-430, 2007 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 4
  • Basım Tarihi: 2007
  • Dergi Adı: Journal of the Turkish German Gynecology Association
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.428-430
  • Anahtar Kelimeler: low dose human chorionic gonadotrophin, hypogonadotrophic hypogonadism, ovulation induction, assisted reproduction
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

In this case report, we present a 34-year old woman with hypogonadotrophic hypogonadism in which we used low dose human chorionic gonadotrophin (150 IU/day) as luteinizing hormone supplement after priming with recombinant follicle stimulating hormone in an assisted reproduction cycle. Twenty-five oocytes were retrieved, 14 oocytes underwent intracytoplasmic sperm injection and 13 were fertilized and all of them cleaved. Four embryos were transferred on day 2. The result was a twin pregnancy. The patient had an uneventful pregnancy and at 38th weeks of gestation delivered two healthy female and male infants weighing 3015 g and 2876 g, respectively. As a conclusion, low dose human chorionic gonadotrophin administration in the late follicular phase of the ovulation induction cycle may be an effective way to provide luteinizing hormone like activity in hypogonadotrophic patients. Randomized controlled studies are needed to support this conclusion.